MAROXEPIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H19NO
Molecular Weight	277.3603
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC2=C(CC1)C3=CC=CC=C3OC4=CC=CC=C24

InChI

InChIKey=RLYFYCIACXEKPZ-UHFFFAOYSA-N

InChI=1S/C19H19NO/c1-20-12-10-14-15(11-13-20)17-7-3-5-9-19(17)21-18-8-4-2-6-16(14)18/h2-9H,10-13H2,1H3

HIDE SMILES / InChI

Molecular Formula	C19H19NO
Molecular Weight	277.3603
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800001231 | https://www.ncbi.nlm.nih.gov/pubmed/1812498 | https://link.springer.com/book/10.1007/978-1-4757-2085-3

Maroxepin is a tetracyclic compound antagonizing activity of dopamine receptors. Maroxepin has a potent central nervous action and a strong sedative potential. Maroxepin exerts both antipsychotic and antidepressant properties.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmaco-EEG profile of maroxepine: third example to discuss the predictive value of pharmaco-electroencephalography in early human pharmacological evaluations of psychoactive drugs.	1991-11	1812498
High-affinity antagonists of the locust neuronal octopamine receptor.	1990-11-27	2086239

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:26:35 GMT 2025` Edited by `admin` on `Mon Mar 31 18:26:35 GMT 2025`
Record UNII	XG4094G0OY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MAROXEPIN

Official Name

English

maroxepin [INN]

Preferred Name

English

2,3,4,5-TETRAHYDRO-3-METHYL-1H-DIBENZ(2,3:6,7)OXEPINO(4,5-D)AZEPINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265