U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 20:02:31 GMT 2023
Edited
by admin
on Sat Dec 16 20:02:31 GMT 2023
Protein Type TRANSPORTER
Protein Sub Type ATP-BINDING CASSETTE TRANSPORTER
Sequence Origin CANINE
Sequence Type COMPLETE
Record UNII
XBG3W2GCL2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ATP-dependent translocase ABCB1 [Canis lupus familiaris]
Common Name English
P-Gp (dog)
Common Name English
MULTIDRUG RESISTANCE PROTEIN 1 (CANINE)
Common Name English
MDR-1 (Dog, Beagle)
Common Name English
Code System Code Type Description
FDA UNII
XBG3W2GCL2
Created by admin on Sat Dec 16 20:02:32 GMT 2023 , Edited by admin on Sat Dec 16 20:02:32 GMT 2023
PRIMARY
NCBI Protein
NP_001003215.2
Created by admin on Sat Dec 16 20:02:32 GMT 2023 , Edited by admin on Sat Dec 16 20:02:32 GMT 2023
PRIMARY
Glycosylation Link Type Site
N 1_74
N 1_87
N 1_95
N 1_100
N 1_298
N 1_496
N 1_641
N 1_706
N 1_811
N 1_1036
Related Record Type Details
SUBSTRATE -> TRANSPORTER
Dogs homozygous or heterozygous for the ABCB1-1Δ mutation are significantly more likely than normal dogs to develop haematological and gastrointestinal toxicity.
SUBSTRATE -> TRANSPORTER
Dogs homozygous or heterozygous for the ABCB1-1Δ mutation are significantly more likely than normal dogs to develop haematological and gastrointestinal toxicity.
SUBSTRATE -> TRANSPORTER
Increased sedation seen in dogs with the ABCB1-1Δ mutation.
SUBSTRATE -> TRANSPORTER
Collies were observed to have severe neurological signs after oral administration of ivermectin attributable to an inherited ABCB1-1Δ mutation and its effect on the integrity of the blood–brain barrier.
SUBSTRATE -> TRANSPORTER
Dogs with the ABCB1-1Δ mutation are at risk of developing a severe neurotoxicosis with standard doses of loperamide.
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL