ATP-dependent translocase ABCB1 [Canis lupus familiaris]

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 20:02:31 GMT 2023` Edited by `admin` on `Sat Dec 16 20:02:31 GMT 2023`
Protein Type	TRANSPORTER
Protein Sub Type	ATP-BINDING CASSETTE TRANSPORTER
Sequence Origin	CANINE
Sequence Type	COMPLETE
Record UNII	XBG3W2GCL2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ATP-dependent translocase ABCB1 [Canis lupus familiaris]

Common Name

English

P-Gp (dog)

Common Name

English

MULTIDRUG RESISTANCE PROTEIN 1 (CANINE)

Common Name

English

MDR-1 (Dog, Beagle)

Common Name

English

Code System Code Type Description

FDA UNII

XBG3W2GCL2

Created by admin on Sat Dec 16 20:02:32 GMT 2023 , Edited by admin on Sat Dec 16 20:02:32 GMT 2023

PRIMARY

NCBI Protein

NP_001003215.2

Created by admin on Sat Dec 16 20:02:32 GMT 2023 , Edited by admin on Sat Dec 16 20:02:32 GMT 2023

PRIMARY

Glycosylation Link Type	Site
N	1_74
N	1_87
N	1_95
N	1_100
N	1_298
N	1_496
N	1_641
N	1_706
N	1_811
N	1_1036

Related Record Type Details


					80168379AG

DOXORUBICIN

SUBSTRATE -> TRANSPORTER

Comments:

Dogs homozygous or heterozygous for the ABCB1-1Δ mutation are significantly more likely than normal dogs to develop haematological and gastrointestinal toxicity.

Amount:


					5J49Q6B70F

VINCRISTINE

SUBSTRATE -> TRANSPORTER

Comments:

Dogs homozygous or heterozygous for the ABCB1-1Δ mutation are significantly more likely than normal dogs to develop haematological and gastrointestinal toxicity.

Amount:


					54EJ303F0R

ACEPROMAZINE

SUBSTRATE -> TRANSPORTER

Comments:

Increased sedation seen in dogs with the ABCB1-1Δ mutation.

Amount:


					8883YP2R6D

IVERMECTIN

SUBSTRATE -> TRANSPORTER

Comments:

Collies were observed to have severe neurological signs after oral administration of ivermectin attributable to an inherited ABCB1-1Δ mutation and its effect on the integrity of the blood–brain barrier.

Amount:


					6X9OC3H4II

LOPERAMIDE

SUBSTRATE -> TRANSPORTER

Comments:

Dogs with the ABCB1-1Δ mutation are at risk of developing a severe neurotoxicosis with standard doses of loperamide.

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL