Elegrobart

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 17:20:41 GMT 2025` Edited by `admin` on `Wed Apr 02 17:20:41 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	XB49Z3T6CY
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

VRDN-003

Preferred Name

English

Elegrobart

Official Name

English

elegrobart [INN]

Common Name

English

Immunoglobulin G1 [96-phenylalanine,de-C-terminal lysine], anti-(human insulin-like growth factor I receptor) (human-Mus musculus monoclonal VRDN-003 ?1-chain), disulfide with human-Mus musculus monoclonal VRDN-003 ?-chain, dimer

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens IGF1R (insulin-like growth factor 1 receptor, IGF1-R, IGF-1R, CD221)], monoclonal antibody; H-gamma1 heavy chain (1-453) [VH Musmus/Homsap (Mus musculus IGHV1-69-5*01 (92.9%) -(IGHD) -IGHJ1*01 (93.8%) A120>Q (1

Common Name

English

Code System Code Type Description

INN

13528

Created by admin on Wed Apr 02 17:20:41 GMT 2025 , Edited by admin on Wed Apr 02 17:20:41 GMT 2025

PRIMARY

CAS

2832924-76-0

Created by admin on Wed Apr 02 17:20:41 GMT 2025 , Edited by admin on Wed Apr 02 17:20:41 GMT 2025

PRIMARY

FDA UNII

XB49Z3T6CY

Created by admin on Wed Apr 02 17:20:41 GMT 2025 , Edited by admin on Wed Apr 02 17:20:41 GMT 2025

PRIMARY

From	To
4_139	4_199
4_23	4_93
3_139	3_199
3_23	3_93
2_374	2_432
2_268	2_328
2_227	4_219
2_151	2_207
1_374	1_432
1_268	1_328
1_236	2_236
1_233	2_233
1_227	3_219
1_151	1_207

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_304
N	2_304

Related Record Type Details


					DK7PL4F3TT

INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR

TARGET->LIGAND

Amount:

Related Record Type Details


					XB49Z3T6CY

Elegrobart

ACTIVE MOIETY

Comments:

thyroid eye disease

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL