Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C15H22N2O |
| Molecular Weight | 246.348 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CCCN3CCC[C@]([H])([C@@]4([H])CC=CC(=O)N4C1)[C@]23[H]
InChI
InChIKey=AAGFPTSOPGCENQ-JLNYLFASSA-N
InChI=1S/C15H22N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h1,7,11-13,15H,2-6,8-10H2/t11-,12+,13+,15-/m0/s1
| Molecular Formula | C15H22N2O |
| Molecular Weight | 246.348 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionSources: doi: 10.1248/cpb.13.482Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/24587659 | https://www.ncbi.nlm.nih.gov/pubmed/23395669 | https://www.ncbi.nlm.nih.gov/pubmed/18379053
Sources: doi: 10.1248/cpb.13.482
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/24587659 | https://www.ncbi.nlm.nih.gov/pubmed/23395669 | https://www.ncbi.nlm.nih.gov/pubmed/18379053
Sophocarpine is a dehydrogenation derivative of the bis-quinolizidine alkaloid matrine. Sophocarpine is also an active component in sophora alkaloids, which possess a variety of pharmacological effects such as anti-inflammation, immunity regulation, antivirus, and anti-tumor actions. Sophocarpine is able to block HERG K+ channel. It is Na+ channel inward current inhibitor. It activates the AMPK signaling pathway and inhibits the TLR4-downstream pathway.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL240 |
100.0 µM [IC50] | ||
Target ID: map04152 |
|||
Target ID: Sodium channel |
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Target ID: TLR4 signaling pathway |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Mechanism of sophocarpine in treating experimental colitis in mice]. | 2015 Aug |
|
| Inhibition of Sophocarpine on Poly I: C/D-GalN-Induced Immunological Liver Injury in Mice. | 2016 |
|
| RETRACTED: Sophocarpine displays anti-inflammatory effect via inhibiting TLR4 and TLR4 downstream pathways on LPS-induced mastitis in the mammary gland of mice. | 2016 Jun |
|
| Differentiation therapy of hepatocellular carcinoma by inhibiting the activity of AKT/GSK-3β/β-catenin axis and TGF-β induced EMT with sophocarpine. | 2016 Jun 28 |
Patents
| Substance Class |
Chemical
Created
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admin
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Edited
Sat Dec 16 09:22:08 GMT 2023
by
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Sat Dec 16 09:22:08 GMT 2023
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| Record UNII |
X9X8U6P2NP
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| Record Status |
Validated (UNII)
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| Record Version |
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