TAT-NR2B9C is a synthetic peptide fusion of the nine C-terminal residues of the NR2B subunit of the N-methyl-D-aspartate (NMDA) receptor and the cell membrane protein transduction domain of the HIV-1 tat protein. It is a postsynaptic density protein-95 (PSD95) inhibitor with neuroprotective properties. It is under development for the treatment of acute stroke and acute cerebral ischemia.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Discovery and development of NA-1 for the treatment of acute ischemic stroke. | 2018-05 |
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| Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat. | 2017-01 |
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| PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. | 2007-09-12 |
| Substance Class |
Protein
Created
by
admin
on
Edited
Wed Apr 02 05:00:52 GMT 2025
by
admin
on
Wed Apr 02 05:00:52 GMT 2025
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| Protein Type | PEPTIDE |
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
X90D3LLT2N
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| Record Status |
FAILED
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| Record Version |
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-
Download
| Name | Type | Language | ||
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Official Name | English | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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GH-181
Created by
admin on Wed Apr 02 05:00:52 GMT 2025 , Edited by admin on Wed Apr 02 05:00:52 GMT 2025
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PRIMARY | |||
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2273883-75-1
Created by
admin on Wed Apr 02 05:00:52 GMT 2025 , Edited by admin on Wed Apr 02 05:00:52 GMT 2025
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NON-SPECIFIC STOICHIOMETRY | |||
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155558145
Created by
admin on Wed Apr 02 05:00:52 GMT 2025 , Edited by admin on Wed Apr 02 05:00:52 GMT 2025
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PRIMARY | PUBCHEM | ||
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X90D3LLT2N
Created by
admin on Wed Apr 02 05:00:52 GMT 2025 , Edited by admin on Wed Apr 02 05:00:52 GMT 2025
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PRIMARY | |||
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C174945
Created by
admin on Wed Apr 02 05:00:52 GMT 2025 , Edited by admin on Wed Apr 02 05:00:52 GMT 2025
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PRIMARY | |||
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300000023172
Created by
admin on Wed Apr 02 05:00:52 GMT 2025 , Edited by admin on Wed Apr 02 05:00:52 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| MOIETY |
Amount:
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Acetic acid | Q40Q9N063P |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| Molecular Formula | CHEMICAL |
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| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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