OM-301

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 19:22:06 GMT 2023` Edited by `admin` on `Sat Dec 16 19:22:06 GMT 2023`
Protein Type	FUSION PROTEINS
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	X8K6U56JL4
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

OM-301

Common Name

English

Pro-Pro-Leu-Ser-Gln-Gln-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met- Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly

Common Name

English

Glycine, L-prolyl-L-prolyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-threonyl-Lphenylalanyl- L-seryl-L-alpha-aspartyl-L-leucyl-L-tryptophyl-L-lysyl-L-leucyl-L-leucyl-L-lysyl-Llysyl- L-tryptophyl-L-lysyl-L-methionyl-L-arginyl-L-arginyl-L-asparaginy

Systematic Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

855021

Created by admin on Sat Dec 16 19:22:06 GMT 2023 , Edited by admin on Sat Dec 16 19:22:06 GMT 2023

Code System Code Type Description

FDA UNII

X8K6U56JL4

Created by admin on Sat Dec 16 19:22:06 GMT 2023 , Edited by admin on Sat Dec 16 19:22:06 GMT 2023

PRIMARY

Related Record Type Details


					J3XT2E65NQ

E3 UBIQUITIN-PROTEIN LIGASE MDM2

TARGET->LIGAND

Comments:

Fusion protein that binds HDM2 on cancer cells and leads to lysis of cell. p53-independent HDM2 expression has been reported on the membrane of cancer cells but not on that of normal cells. Herein, we first showed that membrane HDM2 (mHDM2) is exclusively expressed on human and mouse AML blasts, including leukemia stem cell (LSC)-enriched subpopulations, but not on normal hematopoietic stem cells (HSCs).

Amount:

Related Record Type Details


					X8K6U56JL4

OM-301

ACTIVE MOIETY

Comments:

Fusion protein

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL