TECHNETIUM TC-99M MEDRONATE

First approved in 1973

Details

Stereochemistry	ACHIRAL
Molecular Formula	CH2O6P2.Tc.2H2O
Molecular Weight	306.9073
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	-4

SHOW SMILES / InChI

Structure of TECHNETIUM TC-99M MEDRONATE

Structure Search

SMILES

O.O.[99Tc].[O-]P([O-])(=O)CP([O-])([O-])=O

InChI

InChIKey=GEJDKFSIZBOWEL-SGNQUONSSA-J

InChI=1S/CH6O6P2.2H2O.Tc/c2-8(3,4)1-9(5,6)7;;;/h1H2,(H2,2,3,4)(H2,5,6,7);2*1H2;/p-4/i;;;1+1

HIDE SMILES / InChI

Molecular Formula	CH4O6P2
Molecular Weight	173.9864
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Tc
Molecular Weight	98.9063
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.hindawi.com/journals/stni/2014/839369/
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/books/NBK215133/ | https://www.iaea.org/OurWork/ST/NE/NEFW/Technical-Areas/RRS/documents /mo99/WORKINGMATERIALSmo99CM.pdf | https://www.ncbi.nlm.nih.gov/pubmed/27854401

Molybdenum-99 (99Mo, half-life = 66 h) is a parent radionuclide of a diagnostic nuclear isotope. It decays in technetium-99 m (half-life = 6 h), which is used in over 30 million procedures per year around the world. Between 95 and 98 percent of Mo-99 is currently being produced using highly enriched uranium (HEU) targets. Other medical isotopes such as iodine-131 (I-131) and xenon-133 (Xe-133) are by-products of the Mo-99 production process and will be sufficiently available if Mo-99 is available.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
bone problems 43 Sources: https://www.drugs.com/cons/osteolite.html	Diagnostic	Approved 8429	OSTEOLITE Approved Use Unknown Launch Date 1977
osteogenesis 43 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018035s032lbl.pdf	Diagnostic	Approved 8429	DRAXIMAGE MDP-10 Approved Use MDP-25 (Kit for the Preparation of Technetium Tc 99m Medronate) may be used as a bone imaging agent to delineate areas of altered osteogenesis. Launch Date 1978

PubMed

Title	Date	PubMed
Future of low specific activity molybdenum-99/technetium-99m generator.	2012 Oct	22642420

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:49:27 GMT 2023` Edited by `admin` on `Fri Dec 15 15:49:27 GMT 2023`
Record UNII	X89XV46R07
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TECHNETIUM TC-99M MEDRONATE

Common Name

English

TECHNETIUM ((SUP 99M)TC) METHYLENEDIPHOSPHONATE

Common Name

English

TECHNETIUM TC-99M MEDRONATE [ORANGE BOOK]

Common Name

English

TECHNETIUM-99TC, DIAQUA((METHYLENEBIS(PHOSPHONATO-.KAPPA.O))(4-))-

Systematic Name

English

Technetium tc 99m medronate [WHO-DD]

Common Name

English

TECHNETIUM TC 99M MEDRONATE

Common Name

English

PHOSPHONIC ACID, METHYLENEBIS-, TECHNETIUM-99 COMPLEX

Common Name

English

TECHNETIUM TC-99M MEDRONATE KIT [ORANGE BOOK]

Common Name

English

TECHNETIUM-99TC, DIAQUA((METHYLENEBIS(PHOSPHONATO))(4-))-

Systematic Name

English

TECHNETIUM TC 99M MEDRONATE [USP IMPURITY]

Common Name

English

TECHNETIUM-99TC, DIAQUA((P,P'-METHYLENEBIS(PHOSPHONATO-.KAPPA.O))(4-))-

Systematic Name

English

Classification Tree Code System Code

NDF-RT

N0000177914