VUPANORSEN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 14:44:20 GMT 2023` Edited by `admin` on `Sat Dec 16 14:44:20 GMT 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	X70RY8Q6LI
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

VUPANORSEN SODIUM

Official Name

English

VUPANORSEN SODIUM [USAN]

Common Name

English

DNA, D((2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-T-SP-T-SP-G-SP-M5C-SP-M5C-SP-A-SP-G-SP-T-SP-A-SP-A-SP-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RC-(2

Systematic Name

English

AKCEA-ANGPTL3-LRX SODIUM

Code

English

ISIS-703802 SODIUM

Code

English

ISIS 703802 SODIUM

Code

English

Code System Code Type Description

NCI_THESAURUS

C174943

Created by admin on Sat Dec 16 14:44:20 GMT 2023 , Edited by admin on Sat Dec 16 14:44:20 GMT 2023

PRIMARY

CAS

2172852-12-7

Created by admin on Sat Dec 16 14:44:20 GMT 2023 , Edited by admin on Sat Dec 16 14:44:20 GMT 2023

PRIMARY

FDA UNII

X70RY8Q6LI

Created by admin on Sat Dec 16 14:44:20 GMT 2023 , Edited by admin on Sat Dec 16 14:44:20 GMT 2023

PRIMARY

USAN

FG-168

Created by admin on Sat Dec 16 14:44:20 GMT 2023 , Edited by admin on Sat Dec 16 14:44:20 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20
Deoxyribose (DNA)	1_6-1_15	10 / 20

Linkage	Site Range	Site Count
	1_2-1_5;1_16-1_17	6 / 19
Sodium Phosporothioate	1_1;1_6-1_15;1_18-1_19	13 / 19

Related Record Type Details


					A7YG62NHZ6

VUPANORSEN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Extent	Fragment Name	Fragment Approval
MOIETY		RESIDUE_SPECIFIC	Amount:	SODIUM CATION	LYR4M0NH37
NUCLEOSIDE_SUBSTITUTION	[1_9] [1_10]	SITE_SPECIFIC		5-METHYLDEOXYCYTIDINE	B200GV71QM
NUCLEOSIDE_SUBSTITUTION	[1_4] [1_17] [1_19]	SITE_SPECIFIC		2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE	AOQ54IZZ6J
NUCLEOSIDE_SUBSTITUTION	[1_1]	5'-TERMINUS		UNSPECIFIED SUBSTANCE	91ce9173 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL