VUPANORSEN SODIUM

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 00:55:49 GMT 2025` Edited by `admin` on `Wed Apr 02 00:55:49 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Type	COMPLETE
Record UNII	X70RY8Q6LI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AKCEA-ANGPTL3-LRX SODIUM

Preferred Name

English

VUPANORSEN SODIUM

Official Name

English

VUPANORSEN SODIUM [USAN]

Common Name

English

DNA, D((2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-T-SP-T-SP-G-SP-M5C-SP-M5C-SP-A-SP-G-SP-T-SP-A-SP-A-SP-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RC-(2

Systematic Name

English

ISIS-703802 SODIUM

Code

English

ISIS 703802 SODIUM

Code

English

Code System Code Type Description

NCI_THESAURUS

C174943

Created by admin on Wed Apr 02 00:55:49 GMT 2025 , Edited by admin on Wed Apr 02 00:55:49 GMT 2025

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SMS_ID

300000011145

Created by admin on Wed Apr 02 00:55:49 GMT 2025 , Edited by admin on Wed Apr 02 00:55:49 GMT 2025

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CAS

2172852-12-7

Created by admin on Wed Apr 02 00:55:49 GMT 2025 , Edited by admin on Wed Apr 02 00:55:49 GMT 2025

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FDA UNII

X70RY8Q6LI

Created by admin on Wed Apr 02 00:55:49 GMT 2025 , Edited by admin on Wed Apr 02 00:55:49 GMT 2025

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USAN

FG-168

Created by admin on Wed Apr 02 00:55:49 GMT 2025 , Edited by admin on Wed Apr 02 00:55:49 GMT 2025

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Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20
Deoxyribose (DNA)	1_6-1_15	10 / 20

Linkage	Site Range	Site Count
	1_2-1_5;1_16-1_17	6 / 19
Sodium Phosporothioate	1_1;1_6-1_15;1_18-1_19	13 / 19

Related Record Type Details


					A7YG62NHZ6

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
MOIETY		RESIDUE_SPECIFIC		Amount:	Sodium cation	LYR4M0NH37
NUCLEOSIDE_SUBSTITUTION	[1_9] [1_10]	SITE_SPECIFIC			5-METHYLDEOXYCYTIDINE	B200GV71QM
NUCLEOSIDE_SUBSTITUTION	[1_4] [1_17] [1_19]	SITE_SPECIFIC			2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE	AOQ54IZZ6J
NUCLEOSIDE_SUBSTITUTION	[1_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	91ce9173 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL