EMERAMIDE POTASSIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N2O2S2.2K
Molecular Weight	360.578
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[K+].[K+].[S-]CCNC(=O)C1=CC(=CC=C1)C(=O)NCC[S-]

InChI

InChIKey=FRTPMZXZBMRSIF-UHFFFAOYSA-L

InChI=1S/C12H16N2O2S2.2K/c15-11(13-4-6-17)9-2-1-3-10(8-9)12(16)14-5-7-18;;/h1-3,8,17-18H,4-7H2,(H,13,15)(H,14,16);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	C12H16N2O2S2
Molecular Weight	284.398
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://emeramed.com/ | https://emeramed.com/irminix-safe-metals-chelator/ | https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu3171864

Emeramide or Irminix® (N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI)) is a lipid-soluble thiol-redox antioxidant and heavy metal chelator. Orphan Drug Designation has been granted for the prevention and treatment of mercury toxicity in the EU and USA. Phase 1 and Phase 2a clinical studies have been performed and found Irminix® to be effective and safe with no adverse effects. A Phase 2a clinical trial for the treatment of chronic obstructive pulmonary disease has been completed in summer of 2018 and found Irminix® to be safe with no adverse effects.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells.	2011 Dec	21994240
Amelioration of Acute Mercury Toxicity by a Novel, Non-Toxic Lipid Soluble Chelator N,N'bis-(2-mercaptoethyl)isophthalamide: Effect on Animal Survival, Health, Mercury Excretion and Organ Accumulation.	2012	22573916
Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamide.	2012 Jun	22409285

Sample Use Guides

In Vivo Use Guide

For the 14 days of the intervention 100 mg NBMI, 300 mg NBMI or placebo were administered orally to all patients.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 00:26:34 GMT 2023` Edited by `admin` on `Sat Dec 16 00:26:34 GMT 2023`
Record UNII	X5D79X18ST
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EMERAMIDE POTASSIUM

Common Name

English

1,3-BENZENEDICARBOXAMIDE, N1,N3-BIS(2-MERCAPTOETHYL)-, POTASSIUM SALT (1:2)

Systematic Name

English

Emeramide potassium [WHO-DD]

Common Name

English

1,3-BENZENEDICARBOXAMIDE, N,N'-BIS(2-MERCAPTOETHYL)-, DIPOTASSIUM SALT

Systematic Name

English

EMERAMIDE DIPOTASSIUM

Common Name

English

Code System Code Type Description

CAS

406676-54-8