Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C29H50O6 |
| Molecular Weight | 494.7037 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 13 / 13 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC[C@@H](C(C)C)[C@H](O)[C@@H](O)[C@@H](C)[C@H]1CC[C@H]2[C@@H]3COC(=O)[C@H]4C[C@H](O)[C@H](O)C[C@]4(C)[C@H]3CC[C@]12C
InChI
InChIKey=HJIKODJJEORHMZ-DNVPGCTHSA-N
InChI=1S/C29H50O6/c1-7-17(15(2)3)26(33)25(32)16(4)19-8-9-20-18-14-35-27(34)22-12-23(30)24(31)13-29(22,6)21(18)10-11-28(19,20)5/h15-26,30-33H,7-14H2,1-6H3/t16-,17-,18-,19+,20-,21-,22+,23-,24+,25-,26-,28+,29+/m0/s1
| Molecular Formula | C29H50O6 |
| Molecular Weight | 494.7037 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 13 / 13 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/21491949
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21491949
(22S,23S)-homobrassinolide (also known as isohomobrassinolide) is a member of the plant-derived polyhydroxylated derivatives of 5α-cholestane family of compounds; known as brassinosteroids. It was shown that isohomobrassinolide selectively activates the PI3K/Akt signaling pathway by increasing Akt phosphorylation in vitro.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: map04151 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21491949 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Influence of (22S,23S)-homobrassinolide on rooting capacity and survival of adult Norway spruce cuttings. | 1993-01 |
|
| Studies on steroidal plant-growth regulators (XVII)--a new synthesis of homobrassinolide and (22S, 23S)-22, 23-epi-homobrassinolide. | 1991-06 |
|
| Effects of (22S,23S)-Homobrassinolide and Related Compounds on Membrane Potential and Transport of Egeria Leaf Cells. | 1990-07 |
| Substance Class |
Chemical
Created
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Edited
Mon Mar 31 23:33:05 GMT 2025
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Mon Mar 31 23:33:05 GMT 2025
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