U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 12:39:02 GMT 2023
Edited
by admin
on Sat Dec 16 12:39:02 GMT 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
X4HG9CCA5A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROSTAGLANDIN D2 RECEPTOR 2
Common Name English
CD_ANTIGEN: CD294
Common Name English
PROSTANOID DP2 RECEPTOR
Common Name English
CRTH2
Common Name English
DP2
Common Name English
GPR44
Common Name English
CHEMOATTRACTANT RECEPTOR-HOMOLOGOUS MOLECULE EXPRESSED ON TH2 CELLS
Common Name English
D PROSTANOID RECEPTOR 2
Common Name English
G-PROTEIN COUPLED RECEPTOR 44
Common Name English
DL1R
Common Name English
Code System Code Type Description
UNIPROT
Q9Y5Y4
Created by admin on Sat Dec 16 12:39:02 GMT 2023 , Edited by admin on Sat Dec 16 12:39:02 GMT 2023
PRIMARY
FDA UNII
X4HG9CCA5A
Created by admin on Sat Dec 16 12:39:02 GMT 2023 , Edited by admin on Sat Dec 16 12:39:02 GMT 2023
PRIMARY
PHAROS
Q9Y5Y4
Created by admin on Sat Dec 16 12:39:02 GMT 2023 , Edited by admin on Sat Dec 16 12:39:02 GMT 2023
PRIMARY
WIKIPEDIA
Prostaglandin DP2 receptor
Created by admin on Sat Dec 16 12:39:02 GMT 2023 , Edited by admin on Sat Dec 16 12:39:02 GMT 2023
PRIMARY
From To
1_104 1_182
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_4
N 1_25
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
A post hoc analysis revealed that the greatest improvement of lung function by timapiprant was observed in patients with active eosinophilia (≥250/μl peripheral blood) and—even more pronounced—in younger patients (90). This applies also for the humanized murine IL-5 antibody mepolizumab, which is most effective and only given in asthma patients with severe eosinophilic airway inflammation (91). In eosinophil esophagitis, timapiprant significantly reduced the esophageal eosinophil load and induced some clinical improvement (92). Timapiprant also successfully reduced nasal and ocular symptoms in allergic subjects exposed to grass pollen (93).
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Kd
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL