METHYLHEXANEAMINE

First approved in 1948

Details

Stereochemistry	MIXED
Molecular Formula	C7H17N
Molecular Weight	115.2166
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(C)CC(C)N

InChI

InChIKey=YAHRDLICUYEDAU-UHFFFAOYSA-N

InChI=1S/C7H17N/c1-4-6(2)5-7(3)8/h6-7H,4-5,8H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C7H17N
Molecular Weight	115.2166
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22566490 | https://www.fda.gov/food/dietarysupplements/productsingredients/ucm346576.htm

METHYLHEXANEAMINE, an amphetamine derivative, is also known as 1,3-dimethylamylamine (DMAA). It was introduced in 1948 as a nasal inhaler for allergic or infectious rhinitis. By the 1970s, it had been withdrawn from the market. DMAA is currently used as an ingredient in many sports performance and weight loss products. According to FDA, it is not a dietary ingredient, and DMAA-containing products marketed as dietary supplements are illegal and their marketing violates the law.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
allergic rhinitis 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15428236	Primary		Withdrawn	Forthane Approved Use Methylhexamine, a volatile sympathomimetic amine base, and its salts share the actions and uses of other vasoconstrictor agents. Methylhexamine is used as an inhalant for its local vasoconstrictor action on the nasal mucosa. This treatment produces temorary relief of nasal congestion and is used as an adjunct in the treatment of allergic or infectious rhinitis and sinusitis. For this purpose the drug is supplied in the form of the carbonate which readily releases the volatile base when the inhaler is opened. This method of local application of the drug produces little or no effect upon the pulse rate or blood pressure of adult humans.

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 1587		inhibitor 1852

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP2D6 1891	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/26360628/	yes [IC50 2 uM]
CYP3A4 1925	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/26360628/	yes

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY504208	https://www.001chemical.com/chem/105-41-9
3B Scientific (Wuhan) Corp	3B3-021641	http://www.3bsc.com/index/pro_info.php?id=43717
AA Blocks	AA003LP8	https://www.aablocks.com/goods/Goods/detail?id=AA003LP8
AEchem Scientific Corp., USA	AE025977	http://www.aechemsc.com/info_products/AE025977.php
AHH Chemical co.,ltd	MT-33061	http://www.ahhchemical.com/product/MT-33061.html
AK Scientific, Inc. (AKSCI)	V1833	http://www.aksci.com/item_detail.php?cat=V1833
Acadechem	ACDX-013415	http://acadechemical.com/product/88108
Acadechem	ACDS-026695	http://www.acadechemical.com/product/101394
Achemtek	0104-023512	http://www.achemtek.com/105-41-9
Alichem	490017964	http://www.alichem.com/en/products/105-41-9.html
Allbio Pharm Co., Ltd	AD12139	http://www.allbiopharm.com/product/n/AD12139
Angene	AGN-PC-05RCXT	http://www.angenechemical.com/productshow/AGN-PC-05RCXT.html
Aurora Fine Chemicals LLC	A05.891.826	http://online.aurorafinechemicals.com/info?ID=A05.891.826
Aurum Pharmatech LLC	M-3563	http://www.Aurumpharmatech.com/Product/ProductDetails/M_3563
BioChemPartner	BCP18792	http://www.biochempartner.com/105-41-9-BCP18792
BioSynth	W-108787	https://www.biosynth.com/en/products/chemical-intermediates/basic-intermediates/products/W-108787.html
ChemMol	49409637	http://www.chemmol.com/chemmol/49409637.html
ChemShuttle	159488	http://www.chemshuttle.com/catalogsearch/result/?q=105-41-9&cat=
Chemspace	CSSB00000763587	https://chem-space.com/CSSB00000763587
Debye Scientific	DB-040620	http://www.debyesci.com/cas_105-41-9.html
Hairui	HR123488	http://www.hairuichem.com/en/product/105-41-9.html
Hefei Hirisun Pharmatech Co., Ltd	HR130960	http://hirisunpharm.com/105-41-9.html
Molcore	MC504208	https://www.molcore.com/product/105-41-9
Nextpeptide	NP18062	http://www.nextpeptide.com/105-41-9.html
OChem	12068	http://www.ocheminc.com/index.php?act=psearch&pid=105D419
Parchem	34322	https://www.parchem.com/chemical-supplier-distributor/1-3-dimethylamylamine-HCL-(DMAA)-034322.aspx
Sigma-Aldrich	93909_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/93909?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	SML0460_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/sml0460?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S011038	http://www.sinfoobiotech.com/product/1014436
Smolecule	S590738	https://www.smolecule.com/products/s590738
THE BioTek	bt-308582	https://www.thebiotek.com/product/others/bt-308582
abcr GmbH	AB336933	http://www.abcr.com/shop/en/AB336933
eNovation Chemicals	D523636	http://www.enovationchem.com/productDetails.asp?productID=D523636
mcule	MCULE-2633957870	https://mcule.com/MCULE-2633957870/

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:24:40 GMT 2023` Edited by `admin` on `Fri Dec 15 15:24:40 GMT 2023`
Record UNII	X49C572YQO
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METHYLHEXANEAMINE

Systematic Name

English

4-METHYL-2-HEXANAMINE

Systematic Name

English

FLORADRENE

Brand Name

English

GERANAMINE

Brand Name

English

DIMETHYLAMYLAMINE

Systematic Name

English

1,3-DIMETHYLAMYLAMINE

Systematic Name

English

2-AMINO-4-METHYLHEXANE

Systematic Name

English

METHYLHEXANEAMINE [MI]

Common Name

English

NSC-1106

Code

English

FORTHANE

Brand Name

English

DMAA

Common Name

English

METHYLHEXANAMINE

Systematic Name

English

Methylhexaneamine [WHO-DD]

Common Name

English

Classification Tree Code System Code

DSLD

1141 (Number of products:5)