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Details

Stereochemistry MIXED
Molecular Formula C7H17N
Molecular Weight 115.2166
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of METHYLHEXANEAMINE

SMILES

CCC(C)CC(C)N

InChI

InChIKey=YAHRDLICUYEDAU-UHFFFAOYSA-N
InChI=1S/C7H17N/c1-4-6(2)5-7(3)8/h6-7H,4-5,8H2,1-3H3

HIDE SMILES / InChI
Molecular Formula C7H17N
Molecular Weight 115.2166
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

METHYLHEXANEAMINE, an amphetamine derivative, is also known as 1,3-dimethylamylamine (DMAA). It was introduced in 1948 as a nasal inhaler for allergic or infectious rhinitis. By the 1970s, it had been withdrawn from the market. DMAA is currently used as an ingredient in many sports performance and weight loss products. According to FDA, it is not a dietary ingredient, and DMAA-containing products marketed as dietary supplements are illegal and their marketing violates the law.

Originator

Approval Year

1948
95
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Forthane

Approved Use

Methylhexamine, a volatile sympathomimetic amine base, and its salts share the actions and uses of other vasoconstrictor agents. Methylhexamine is used as an inhalant for its local vasoconstrictor action on the nasal mucosa. This treatment produces temorary relief of nasal congestion and is used as an adjunct in the treatment of allergic or infectious rhinitis and sinusitis. For this purpose the drug is supplied in the form of the carbonate which readily releases the volatile base when the inhaler is opened. This method of local application of the drug produces little or no effect upon the pulse rate or blood pressure of adult humans.
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inhibitor
1587
inhibitor
1852

OverviewOther

Other InhibitorOther SubstrateOther Inducer
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP2D6
1891
 yes [IC50 2 uM]
CYP3A4
1925
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY504208
https://www.001chemical.com/chem/105-41-9
3B Scientific (Wuhan) Corp
3B3-021641
http://www.3bsc.com/index/pro_info.php?id=43717
AA Blocks
AA003LP8
https://www.aablocks.com/goods/Goods/detail?id=AA003LP8
AEchem Scientific Corp., USA
AE025977
http://www.aechemsc.com/info_products/AE025977.php
AHH Chemical co.,ltd
MT-33061
http://www.ahhchemical.com/product/MT-33061.html
AK Scientific, Inc. (AKSCI)
V1833
http://www.aksci.com/item_detail.php?cat=V1833
Acadechem
ACDX-013415
http://acadechemical.com/product/88108
Acadechem
ACDS-026695
http://www.acadechemical.com/product/101394
Achemtek
0104-023512
http://www.achemtek.com/105-41-9
Alichem
490017964
http://www.alichem.com/en/products/105-41-9.html
Allbio Pharm Co., Ltd
AD12139
http://www.allbiopharm.com/product/n/AD12139
Angene
AGN-PC-05RCXT
http://www.angenechemical.com/productshow/AGN-PC-05RCXT.html
Aurora Fine Chemicals LLC
A05.891.826
http://online.aurorafinechemicals.com/info?ID=A05.891.826
Aurum Pharmatech LLC
M-3563
http://www.Aurumpharmatech.com/Product/ProductDetails/M_3563
BioChemPartner
BCP18792
http://www.biochempartner.com/105-41-9-BCP18792
BioSynth
W-108787
https://www.biosynth.com/en/products/chemical-intermediates/basic-intermediates/products/W-108787.html
ChemMol
49409637
http://www.chemmol.com/chemmol/49409637.html
ChemShuttle
159488
http://www.chemshuttle.com/catalogsearch/result/?q=105-41-9&cat=
Chemspace
CSSB00000763587
https://chem-space.com/CSSB00000763587
Debye Scientific
DB-040620
http://www.debyesci.com/cas_105-41-9.html
Hairui
HR123488
http://www.hairuichem.com/en/product/105-41-9.html
Hefei Hirisun Pharmatech Co., Ltd
HR130960
http://hirisunpharm.com/105-41-9.html
Molcore
MC504208
https://www.molcore.com/product/105-41-9
Nextpeptide
NP18062
http://www.nextpeptide.com/105-41-9.html
OChem
12068
http://www.ocheminc.com/index.php?act=psearch&pid=105D419
Parchem
34322
https://www.parchem.com/chemical-supplier-distributor/1-3-dimethylamylamine-HCL-(DMAA)-034322.aspx
Sigma-Aldrich
93909_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/93909?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
SML0460_SIGMA
https://www.sigmaaldrich.com/catalog/product/sigma/sml0460?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech
S011038
http://www.sinfoobiotech.com/product/1014436
Smolecule
S590738
https://www.smolecule.com/products/s590738
THE BioTek
bt-308582
https://www.thebiotek.com/product/others/bt-308582
abcr GmbH
AB336933
http://www.abcr.com/shop/en/AB336933
eNovation Chemicals
D523636
http://www.enovationchem.com/productDetails.asp?productID=D523636
mcule
MCULE-2633957870
https://mcule.com/MCULE-2633957870/
PubMed

PubMed

TitleDatePubMed
Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometry.
2010 Jun 15
Stimulants and doping in sport.
2010 Mar
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:24:40 UTC 2023
Edited
by admin
on Fri Dec 15 15:24:40 UTC 2023
Record UNII
X49C572YQO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
METHYLHEXANEAMINE
MI   WHO-DD  
Systematic Name English
4-METHYL-2-HEXANAMINE
Systematic Name English
FLORADRENE
Brand Name English
GERANAMINE
Brand Name English
DIMETHYLAMYLAMINE
Systematic Name English
1,3-DIMETHYLAMYLAMINE
Systematic Name English
2-AMINO-4-METHYLHEXANE
Systematic Name English
METHYLHEXANEAMINE [MI]
Common Name English
NSC-1106
Code English
FORTHANE
Brand Name English
DMAA
Common Name English
METHYLHEXANAMINE
Systematic Name English
Methylhexaneamine [WHO-DD]
Common Name English
Classification Tree Code System Code
DSLD 1141 (Number of products:5)
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
WIKIPEDIA Designer-drugs-Methylhexanamine
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
DSLD 1227 (Number of products:65)
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
Code System Code Type Description
DRUG CENTRAL
3353
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
PUBCHEM
7753
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
HSDB
8164
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
FDA UNII
X49C572YQO
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
EVMPD
SUB182370
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
CAS
105-41-9
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
SMS_ID
100000168769
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
ECHA (EC/EINECS)
203-296-1
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
WIKIPEDIA
METHYLHEXANAMINE
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
NSC
1106
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
MERCK INDEX
m7427
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID60861715
Created by admin on Fri Dec 15 15:24:40 UTC 2023 , Edited by admin on Fri Dec 15 15:24:40 UTC 2023
PRIMARY
NIH
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