ELZASONAN HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H23Cl2N3OS.ClH
Molecular Weight	484.869
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN1CCN(CC1)C2=CC=CC=C2\C=C3/SCCN(C3=O)C4=CC=C(Cl)C(Cl)=C4

InChI

InChIKey=NMTRXBJYASHMND-UXTSPRGOSA-N

InChI=1S/C22H23Cl2N3OS.ClH/c1-25-8-10-26(11-9-25)20-5-3-2-4-16(20)14-21-22(28)27(12-13-29-21)17-6-7-18(23)19(24)15-17;/h2-7,14-15H,8-13H2,1H3;1H/b21-14-;

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C22H23Cl2N3OS
Molecular Weight	448.409
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800018143 | https://onlinelibrary.wiley.com/doi/full/10.1002/9781118541203.xen439

Elzasonan (CP 448187) is a serotonin 1B/1D receptor antagonist. Elzasonan was primarily metabolized via oxidative N‐demethylation, N‐oxidation, and aryl hydroxylation. Pfizer was developing elzasonan for the treatment of anxiety and affective disorders however development has been discontinued.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays.	2013 Jun 17	23611293

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:35:16 GMT 2023` Edited by `admin` on `Fri Dec 15 15:35:16 GMT 2023`
Record UNII	X38F62RR8L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ELZASONAN HYDROCHLORIDE

Official Name

English

CP-448,187-01

Code

English

CP-448187-01

Code

English

3-THIOMORPHOLINONE, 4-(3,4-DICHLORPHENYL)-2-(((2-(4-METHYL-1-PIPERAZINYL)PHENYL)METHYLENE)- MONOHYDROCHLORIDE, (2Z)-

Common Name

English

ELZASONAN HCL

Common Name

English

ELZASONAN HYDROCHLORIDE [USAN]

Common Name

English

(2Z)-4-(3,4-Dichlorophenyl)-2-[2-(4-methylpiperazin-1-yl)benzylidene]thiomorpholin-3-one monohydrochloride

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66885