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Details

Stereochemistry ACHIRAL
Molecular Formula C23H15N3O2
Molecular Weight 365.385
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DES(2-CYANOPHENYL)-(2-CYANO-4-HYDROXYPHENYL)PERAMPANEL

SMILES

c1ccc(cc1)-n2cc(cc(-c3ccc(cc3C#N)O)c2=O)-c4ccccn4

InChI

InChIKey=LTKVPVLPRNJRJD-UHFFFAOYSA-N
InChI=1S/C23H15N3O2/c24-14-16-12-19(27)9-10-20(16)21-13-17(22-8-4-5-11-25-22)15-26(23(21)28)18-6-2-1-3-7-18/h1-13,15,27H

HIDE SMILES / InChI

Molecular Formula C23H15N3O2
Molecular Weight 365.385
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Sat Jun 26 08:38:46 UTC 2021
Edited
by admin
on Sat Jun 26 08:38:46 UTC 2021
Record UNII
X376H44R70
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DES(2-CYANOPHENYL)-(2-CYANO-4-HYDROXYPHENYL)PERAMPANEL
Common Name English
PERAMPANEL METABOLITE M4
Common Name English
5-HYDROXY-2-(6'-OXO-1'-PHENYL-1',6'-DIHYDRO-(2,3'-BIPYRIDIN)-5'-YL)BENZONITRILE
Systematic Name English
Code System Code Type Description
FDA UNII
X376H44R70
Created by admin on Sat Jun 26 08:38:46 UTC 2021 , Edited by admin on Sat Jun 26 08:38:46 UTC 2021
PRIMARY
PUBCHEM
91800174
Created by admin on Sat Jun 26 08:38:46 UTC 2021 , Edited by admin on Sat Jun 26 08:38:46 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> METABOLITE INACTIVE
In vitro studies show that the primary oxidative metabolic route of perampanel is via cytochrome P450 (CYP)3A4 and/or CYP3A5, based on the results of metabolism by recombinant human CYPs, and inhibition studies using anti-CYP3A4 and ketoconazole in human liver microsomes.
FECAL; URINE