SPICLAMINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H25ClN2O
Molecular Weight	344.878
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(C=C1)[C@@H]2[C@H]3CC[C@H](C3)[C@]24CCC(=N4)N5CCOCC5

InChI

InChIKey=KIYTZWUWLDEAMW-LNKGRISISA-N

InChI=1S/C20H25ClN2O/c21-17-5-2-14(3-6-17)19-15-1-4-16(13-15)20(19)8-7-18(22-20)23-9-11-24-12-10-23/h2-3,5-6,15-16,19H,1,4,7-13H2/t15-,16+,19+,20+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H25ClN2O
Molecular Weight	344.878
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14296621 | https://www.ncbi.nlm.nih.gov/pubmed/5890448

Spiclamine (Epsilamine) is a hemostatic agent. It was administered to a total of 23 patients with urological diseases, including 8 postoperative cases. Marked effective, effective and ineffecgive responses were observed in 8, 10 and 5 cases respectively, making 78.3 % of effectiveness. In cases of so-called essential renal bleeding and prostatic disease, a particularly beneticial result was obtained making 93.3 % of marked effectiveness. No serious side effects was seen in all cases treated.

Approval Year

PubMed

Title	Date	PubMed
[USE OF "EPSILAMINE" AS HEMOSTATICS AT UROLOGICAL CLINIC].	1965 Feb	14296621
[Epsilamine as a hemostatic agent in postoperative hemorrhage in sinus operations].	1965 Jul	5890448

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:43:39 GMT 2023` Edited by `admin` on `Sat Dec 16 16:43:39 GMT 2023`
Record UNII	X1IEH0PMG2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SPICLAMINE

Official Name

English

spiclamine [INN]

Common Name

English

(-)-(1R,2R,3S,4S)-3-(P-CHLOROPHENYL)-2'-MORPHOLINOSPIRO(NORBORNANE-2,5'-(1)PYRROLINE)

Common Name

English

Code System Code Type Description

CAS

90243-97-3