PYRATHIAZINE HYDROCHLORIDE

First approved in 1949

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H20N2S.ClH
Molecular Weight	332.891
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.C(CN1C2=C(SC3=C1C=CC=C3)C=CC=C2)N4CCCC4

InChI

InChIKey=VDOLRBJLUIFCGO-UHFFFAOYSA-N

InChI=1S/C18H20N2S.ClH/c1-3-9-17-15(7-1)20(14-13-19-11-5-6-12-19)16-8-2-4-10-18(16)21-17;/h1-4,7-10H,5-6,11-14H2;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C18H20N2S
Molecular Weight	296.43
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15419574 | https://www.drugs.com/international/parathiazine.html

PARATHIAZINE, a member of phenothiazines, is a histamine receptor antagonist used for the treatment of allergic diseases. Also, it can be used as an antiemetic agent.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergy 44 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15419574	Primary		Not Provided 504	Pyrrolazote Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1VN7
ABI Chem	AC1Q28UQ
Aurora Fine Chemicals LLC	A18.009.878	http://online.aurorafinechemicals.com/info?ID=A18.009.878
Aurora Fine Chemicals LLC	K14.770.920	http://online.aurorafinechemicals.com/info?ID=K14.770.920
BLD Pharm	BD396061	http://www.bldpharm.com/products/84-08-2.html
BOC Sciences	84-08-2	https://www.bocsci.com/parathiazine-cas-84-08-2-item-137246.html
Chemieliva Pharmaceutical Co., Ltd	PBCM0000220
Frontier Scientific Services	100083889
HongKong Chemhere	SCE25724
NCI Plated 2007	62360
NovoSeek	10646
Sigma Aldrich	S811890\|ALDRICH
Sigma-Aldrich	S811890_ALDRICH	http://www.sigmaaldrich.com/catalog/product/aldrich/s811890
THE BioTek	bt-434897	https://www.thebiotek.com/product/others/bt-434897
TimTec	ST50554789
ZINC	ZINC000000002004	http://zinc15.docking.org/substances/ZINC000000002004
eMolecules	1059142
mcule	MCULE-1475912489	https://mcule.com/MCULE-1475912489/

PubMed

Title	Date	PubMed
Clinical report on pyrrolazote; a new antihistaminic drug.	1949 Apr	18124865
Clinical evaluation of pyrrolazote and orthoxine in allergic diseases.	1949 May	18144321
Pyrrolazote, a clinical evaluation in allergic states.	1950 May-Jun	15419574

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:35:08 GMT 2023` Edited by `admin` on `Fri Dec 15 15:35:08 GMT 2023`
Record UNII	X0SMC42Q5O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PYRATHIAZINE HYDROCHLORIDE

Common Name

English

10-(2-(1-PYRROLIDINYL)ETHYL)PHENOTHIAZINE HYDROCHLORIDE

Systematic Name

English

PYRATHIAZINE HCL

Common Name

English

NSC-62360

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29578