CEMDISIRAN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 14:14:18 GMT 2023` Edited by `admin` on `Sat Dec 16 14:14:18 GMT 2023`
Nucleic Acid Type	siRNA
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	X0DZ4POQ4K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CEMDISIRAN SODIUM

Common Name

English

AD-62643

Code

English

RNA, (AM-SP-AM-SP-(2'-DEOXY-2'-FLUORO)G-CM-(2'-DEOXY-2'-FLUORO)A-AM-(2'-DEOXY-2'-FLUORO)G-AM-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)A-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)U-UM-UM-(2'-DEOXY-2'-FLUORO)A-UM-(2'-DEOXY-2'-FLUORO)A-AM-UM-AM), 3'-(((

Systematic Name

English

ALN-62643

Code

English

Code System Code Type Description

FDA UNII

X0DZ4POQ4K

Created by admin on Sat Dec 16 14:14:18 GMT 2023 , Edited by admin on Sat Dec 16 14:14:18 GMT 2023

PRIMARY

CAS

1639267-24-5

Created by admin on Sat Dec 16 14:14:18 GMT 2023 , Edited by admin on Sat Dec 16 14:14:18 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_2-1_3;1_5;1_8;1_10;1_14;1_16;1_18;2_3;2_5;2_7;2_9-2_11;2_13;2_16;2_18	17 / 47
2'-O-Methyl-Ribose	1_1;1_4;1_6-1_7;1_9;1_11-1_13;1_15;1_17;1_19-1_23;2_1-2_2;2_4;2_6;2_8;2_12;2_14-2_15;2_17;2_19-2_21	27 / 47
Deoxyribose (DNA)	1_24-1_25;2_22	3 / 47

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_3;1_22-1_23;2_2-2_3	6 / 45
	1_4-1_21;1_24-1_25;2_4-2_22	39 / 45

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[2_22]	SITE_SPECIFIC	A		CEMDISIRAN, TERMINAL SUGAR MODIFICATION-	CQQ59545BV

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:SEQUNENCE(CALCULATED)	CHEMICAL