METOFLUTHRIN

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14745180
Curator's Comment: Description was created based on several sources, including https://www.sumitomo-chem.co.jp/english/rd/report/theses/docs/20050200_imi.pdf

Metofluthrin is a pyrethroid used as an insect repellent. Metofluthrin exhibits the highest potency, being approximately forty times as potent as d-allethrin in a mosquito coil formulation when tested against southern house mosquitoes (Culex quinquefasciatus). Metofluthrin also exhibits a significant vapor action at room temperature.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
CYP4H42, Aedes albopictus 1 Target ID: CYP4H42, Aedes albopictus Sources: https://www.ncbi.nlm.nih.gov/pubmed/25199940	Activator 1430
CYP4H43, Aedes albopictus 1 Target ID: CYP4H43, Aedes albopictus Sources: https://www.ncbi.nlm.nih.gov/pubmed/25199940	Activator 1430
Cytochrome P450 2B6 19 Target ID: CHEMBL4729 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19378387	Activator 1430
DNA synthesis involved in DNA replication 7 Target ID: GO:0090592 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19378387	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes.	2009 Apr 5	19378387
Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action.	2009 Mar	19176367
Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.	2009 Mar	19176366

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Treatment with 50 uM METOFLUTHRIN and 50 uM PB for 72 h increased CYP2B1 mRNA levels in male Wistar rat hepatocytes and CYP2B6 mRNA levels in human hepatocytes.

Substance Class	Mixture Created by `admin` on `Sat Dec 16 04:59:38 GMT 2023` Edited by `admin` on `Sat Dec 16 04:59:38 GMT 2023`
Record UNII	WZX356S299
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METOFLUTHRIN

Common Name

English

(2,3,5,6-TETRAFLUORO-4-METHOXYMETHYLPHENYL)METHYL-2,2-DIMETHYL-3-(1-PROPENYL)CYCLOPROPANECARBOXYLATE

Systematic Name

English

METOFLUTHRIN [ISO]

Common Name

English

METOFLUTHRIN [JAN]

Common Name

English

METOFLUTHRIN [MI]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

109709