METOFLUTHRIN

Possibly Marketed Outside US

Description

Metofluthrin is a pyrethroid used as an insect repellent. Metofluthrin exhibits the highest potency, being approximately forty times as potent as d-allethrin in a mosquito coil formulation when tested against southern house mosquitoes (Culex quinquefasciatus). Metofluthrin also exhibits a significant vapor action at room temperature.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
CYP4H42, Aedes albopictus 1	Activator 1,447
CYP4H43, Aedes albopictus 1	Activator 1,447
Cytochrome P450 2B6 19	Activator 1,447
DNA synthesis involved in DNA replication 11	Activator 1,447

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2,596

PubMed

Show entries

Title	Date	PubMed
Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes.	2009 Apr 5	19378387
Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action.	2009 Mar	19176367
Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.	2009 Mar	19176366

Showing 1 to 3 of 3 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Treatment with 50 uM METOFLUTHRIN and 50 uM PB for 72 h increased CYP2B1 mRNA levels in male Wistar rat hepatocytes and CYP2B6 mRNA levels in human hepatocytes.