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Details

Stereochemistry ACHIRAL
Molecular Formula C20H24Cl2N10.2ClH
Molecular Weight 548.299
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PICLOXYDINE DIHYDROCHLORIDE

SMILES

Cl.Cl.ClC1=CC=C(NC(=N)NC(=N)N2CCN(CC2)C(=N)NC(=N)NC3=CC=C(Cl)C=C3)C=C1

InChI

InChIKey=VJVSCTKGPDDOBN-UHFFFAOYSA-N
InChI=1S/C20H24Cl2N10.2ClH/c21-13-1-5-15(6-2-13)27-17(23)29-19(25)31-9-11-32(12-10-31)20(26)30-18(24)28-16-7-3-14(22)4-8-16;;/h1-8H,9-12H2,(H4,23,25,27,29)(H4,24,26,28,30);2*1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C20H24Cl2N10
Molecular Weight 475.378
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Picloxydine is a heterocyclic biguanide with antibacterial and antiplaque activity. 0.4% Picloxydine produces a highly significant drop in the number of aerobic organisms. 0.4% Picloxydine is far more effective than 0.2% Picloxydine or chlorhexidine in reducing the total viable count of oral aerobic and anaerobic organisms. It is used to treat superficial eye infections. Picloxydine is also used in eye drops in the topical therapy of trachoma. This drug can cause side effects - local intolerance reactions (temporary irritation, allergic reactions).

Approval Year

Unknown
149124

Sample Use Guides

In Vivo Use Guide
1 drop, 2-6 times per day
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:05:12 GMT 2025
Edited
by admin
on Mon Mar 31 21:05:12 GMT 2025
Record UNII
WZK4CO345V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NSC-148548
Preferred Name English
PICLOXYDINE DIHYDROCHLORIDE
MI   WHO-DD  
Common Name English
1,1'-(1,4-PIPERAZINEDIYLBIS(IMIDOCARBONYL))BIS(3-(P-CHLOROPHENYL)GUANIDINE) DIHYDROCHLORIDE
Common Name English
PICLOXYDINE HYDROCHLORIDE
Common Name English
Picloxydine dihydrochloride [WHO-DD]
Common Name English
PICLOXYDINE DIHYDROCHLORIDE [MI]
Common Name English
Code System Code Type Description
FDA UNII
WZK4CO345V
Created by admin on Mon Mar 31 21:05:12 GMT 2025 , Edited by admin on Mon Mar 31 21:05:12 GMT 2025
PRIMARY
CAS
19803-62-4
Created by admin on Mon Mar 31 21:05:12 GMT 2025 , Edited by admin on Mon Mar 31 21:05:12 GMT 2025
PRIMARY
MERCK INDEX
m8780
Created by admin on Mon Mar 31 21:05:12 GMT 2025 , Edited by admin on Mon Mar 31 21:05:12 GMT 2025
PRIMARY Merck Index
NSC
148548
Created by admin on Mon Mar 31 21:05:12 GMT 2025 , Edited by admin on Mon Mar 31 21:05:12 GMT 2025
PRIMARY
ECHA (EC/EINECS)
243-328-1
Created by admin on Mon Mar 31 21:05:12 GMT 2025 , Edited by admin on Mon Mar 31 21:05:12 GMT 2025
PRIMARY
PUBCHEM
20055534
Created by admin on Mon Mar 31 21:05:12 GMT 2025 , Edited by admin on Mon Mar 31 21:05:12 GMT 2025
PRIMARY
SMS_ID
100000092639
Created by admin on Mon Mar 31 21:05:12 GMT 2025 , Edited by admin on Mon Mar 31 21:05:12 GMT 2025
PRIMARY
EVMPD
SUB03813MIG
Created by admin on Mon Mar 31 21:05:12 GMT 2025 , Edited by admin on Mon Mar 31 21:05:12 GMT 2025
PRIMARY
EPA CompTox
DTXSID70941618
Created by admin on Mon Mar 31 21:05:12 GMT 2025 , Edited by admin on Mon Mar 31 21:05:12 GMT 2025
PRIMARY
NIH
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