U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula K.HO
Molecular Weight 56.1056
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Potassium hydroxide

SMILES

[OH-].[K+]

InChI

InChIKey=KWYUFKZDYYNOTN-UHFFFAOYSA-M
InChI=1S/K.H2O/h;1H2/q+1;/p-1

HIDE SMILES / InChI
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://pubchem.ncbi.nlm.nih.gov/compound/sodium_ion | https://www.ncbi.nlm.nih.gov/pubmed/5107832 | https://www.drugs.com/pro/kayexalate.html | https://www.ncbi.nlm.nih.gov/pubmed/2907018

Sodium is the primary cation (positive ion) in extracellular fluids in animals and humans. Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste. " Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.

CNS Activity

Originator

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Substrate
661
Substrate
661
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
POTASSIUM HYDROXIDE

Approved Use

Used as a softener for nail grooves. Also used as a slide medium in Potassium Hydroxide preparations. Apply to nail in office.

Launch Date

2010
Primary
Phase II
1132
Unknown

Approved Use

Unknown
Primary
Phase III
656
Unknown

Approved Use

Unknown
Primary
Phase II
1132
Unknown

Approved Use

Unknown
Primary
Approved
8429
Kayexalate

Approved Use

INDICATION AND USAGE Kayexalate is indicated for the treatment of hyperkalemia.

Launch Date

1958
PubMed

PubMed

TitleDatePubMed
Age sensitivity to organophosphate-induced delayed polyneuropathy. Biochemical and toxicological studies in developing chicks.
1991 May 15
Immunolocalization and effect of dehydration on AQP3, a basolateral water channel of kidney collecting ducts.
1997 Feb
Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line.
1997 Nov
Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.
1998 Mar 6
Molecular characterization of a broad selectivity neutral solute channel.
1998 Sep 18
Cloning and functional expression of rAOP9L a new member of aquaporin family from rat liver.
1999 Feb
Cr (VI) increases tyrosine phosphorylation through reactive oxygen species-mediated reactions.
2001 Jun
In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis.
2001 Mar 1
Reduced nephrotoxicity of conventional amphotericin B therapy after minimal nephroprotective measures: animal experiments and clinical study.
2002 Aug 1
Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth.
2002 Feb 15
NKCC activity restores muscle water during hyperosmotic challenge independent of insulin, ERK, and p38 MAPK.
2003 Mar
Role of reactive oxygen species and Cr(VI) in Ras-mediated signal transduction.
2004 Jan
The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure.
2006 Jan
Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions.
2007 Dec
Molecular mechanisms of how mercury inhibits water permeation through aquaporin-1: understanding by molecular dynamics simulation.
2010 Apr 21
Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance.
2010 Aug 1
Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia.
2010 Sep 6
Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.
2011 Apr 1
Testosterone modulates pituitary vasotocin receptor expression and adrenal activity in osmotically stressed chicken.
2011 Jan
Inhibition of aquaporin-3 water channel in the colon induces diarrhea.
2012
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.
2012 Jun 1
A novel aquaporin 3 in killifish (Fundulus heteroclitus) is not an arsenic channel.
2012 May
Patents

Patents

03930837
22
03931170
10
03931193
12
03931205
82
03931226
16
03931231
17
03931247
15
03932424
12
03932446
10
03932452
10
03932471
13
03932472
94
03932521
29
03932629
11
03933865
12
03933905
18
03933911
10
03934070
10
03937702
41
03937705
11
03937719
10
03937729
10
03937764
10
03939157
10
03939202
15
03940396
10
03940419
12
03941796
50
03941799
14
03941884
10
03943145
12
03943170
10
03943180
12
03946000
40
03946045
11
03947406
32
03947408
15
03947580
12
03950331
20
03950382
10
03950420
10
03950425
13
03952012
15
03952017
13
03952050
12
03952067
11
03953434
43
03953525
11
03953596
12
03954476
17
03954774
11
03954801
15
03956118
10
03956321
10
03959289
11
03970704
12
04002647
12
04008269
12
04029867
10
04128728
11
04134924
10
04136188
10
04511731
10
04532240
10
04568497
11
04691042
10
04826533
11
04844879
10
05187175
10
05302718
13
05403930
11
05527805
11
05556855
13
05607951
10
05658926
10
06156430
10
06649600
13
06703082
10
07250518
10
07354941
35
07494728
11
07655666
10
08012988
10
08436001
13
08481733
14
08501238
10
08513268
10
08614206
10
08669361
12
08741915
12
20030186989
11
20080153836
11
20090120802
11
20090286768
10
20100144747
11
20110251176
10
20110294818
10
20120208817
10
20130079321
10
20130203732
10
20130217666
10
7820025
11

Sample Use Guides

In Vivo Use Guide
10% Potassium Hydroxide
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:11:23 GMT 2023
Edited
by admin
on Fri Dec 15 16:11:23 GMT 2023
Record UNII
WZH3C48M4T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Potassium hydroxide
EP   FCC   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD  
INCI  
Official Name English
E-525
Code English
KALI CAUSTICUM
HPUS  
Common Name English
POTASSIUM HYDROXIDE [FCC]
Common Name English
POTASSIUM HYDROXIDE [INCI]
Common Name English
CAUSTIC-POTASH
Common Name English
POTASSIUM HYDROXIDE [EP MONOGRAPH]
Common Name English
POTASSIUM HYDROXIDE [VANDF]
Common Name English
POTASSIUM HYDROXIDE [II]
Common Name English
INS-525
Code English
POTASSIUM HYDROXIDE SOLUTION
FCC  
Common Name English
POTASSIUM HYDROXIDE [MI]
Common Name English
POTASSIUM HYDROXIDE [JAN]
Common Name English
INS NO.525
Code English
KALI CAUSTICUM [HPUS]
Common Name English
CAUSTIC POTASH
Common Name English
POTASSIUM HYDROXIDE SOLUTION [FCC]
Common Name English
POTASSIUM HYDROXIDE [MART.]
Common Name English
Potassium hydroxide [WHO-DD]
Common Name English
POTASSIUM HYDROXIDE [HSDB]
Common Name English
POTASSIUM HYDRATE
Systematic Name English
Classification Tree Code System Code
CFR 21 CFR 175.210
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-525
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
CFR 21 CFR 184.1631
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
NCI_THESAURUS C802
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
DSLD 2853 (Number of products:9)
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
JECFA EVALUATION INS-525
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
Code System Code Type Description
HSDB
1234
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
WIKIPEDIA
POTASSIUM HYDROXIDE
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
PUBCHEM
14797
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
MERCK INDEX
m9031
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY Merck Index
MESH
C029943
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
NCI_THESAURUS
C28204
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
SMS_ID
100000091826
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
CHEBI
32035
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-181-3
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
CAS
1310-58-3
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
DAILYMED
WZH3C48M4T
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
RXCUI
34311
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY RxNorm
DRUG BANK
DB11153
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
EVMPD
SUB12560MIG
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
FDA UNII
WZH3C48M4T
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
EPA CompTox
DTXSID5029633
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
ChEMBL
CHEMBL2103983
Created by admin on Fri Dec 15 16:11:23 GMT 2023 , Edited by admin on Fri Dec 15 16:11:23 GMT 2023
PRIMARY
Related Record Type Details
Structure of HYDROXIDE ION
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966