WAY-181187

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H13ClN4O2S2
Molecular Weight	380.872
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCC1=CN(C2=C1C=CC=C2)S(=O)(=O)C3=C(Cl)N=C4SC=CN34

InChI

InChIKey=RYBOXBBYCVOYNO-UHFFFAOYSA-N

InChI=1S/C15H13ClN4O2S2/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20/h1-4,7-9H,5-6,17H2

HIDE SMILES / InChI

Molecular Formula	C15H13ClN4O2S2
Molecular Weight	380.872
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17625499 | https://www.ncbi.nlm.nih.gov/pubmed/21549693 | https://www.ncbi.nlm.nih.gov/pubmed/20217056 | http://adisinsight.springer.com/drugs/800021227

WAY-181187 is a high affinity and selective 5-HT6 agonist. It displays 60-fold selectivity over other 5-HT and monoamine receptors. WAY-181187 stimulates cAMP, ERK1/2 and Fyn kinase signaling pathway through serotonin receptor activation. WAY-181187 produced both antidepressant-like and anxiolytic-like effects in the animal model. It had been in phase I clinical trial for the treatment of anxiety disorders but this research has been discontinued.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 6 (5-HT6) receptor 45 Target ID: CHEMBL3371 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17625499	Agonist 2678		2.2 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anxiety 267 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20217056	Primary		Phase I 428	Unknown Approved Use Unknown
Depression 235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20217056	Primary		Preclinical	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
AstaTech	F17428	http://astatechinc.com/CPSResult.php?CRNO=F17428
Chem Scene	CS-0003294	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-0003294
ChemShuttle	169495	https://www.chemshuttle.com/catalogsearch/result/?q=169495
Excenen	EX-A799	http://www.excenen.com/searchresultlist.php?id=EX-A799
MedChem Express	HY-14340	https://www.medchemexpress.com/search.html?q=HY-14340&ft=&fa=&fp=
MolPort	MolPort-039-101-331	https://www.molport.com/shop/molecule-link/MolPort-039-101-331
Molnova	M17540	https://www.molnova.com/en/serch-list.html?keywords=M17540
MuseChem	I010076	https://www.musechem.com/product/I010076.html
MuseChem	R032234	https://www.musechem.com/product/R032234.html
Tocris	5589	https://www.tocris.com/search.php?Type=QuickSearch&Value=5589
Toronto Research Chemicals	C368405	https://www.trc-canada.com/product-detail/?CatNum=C368405
eMolecules	93435782	https://orderbb.emolecules.com/search/#?query=93435782
eNovation Chemicals	D520879	https://www.enovationchem.com/Products.asp?SEARCHTEXT=D520879&searchbtn.x=0&searchbtn.y=0
mcule	MCULE-3228292685	https://mcule.com/MCULE-3228292685/
mcule	MCULE-6043929533	https://mcule.com/MCULE-6043929533/

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Rat: 10 mg/kg

Route of Administration: Intraperitoneal

In Vitro Use Guide

In hippocampal slice sections, sodium azide (10 mM) treatment significantly increased glutamate (P = 0.0039) release compared with vehicle treatment. Pretreatment of WAY-181187 (0.1–10 uM) significantly and dose-dependently attenuated sodium azide-stimulated increases but did not alter basal amino-acid levels in this in vitro system. P-values comparing doses of WAY-181187 to sodium azide were as follows: glutamate - 0.1 uM, P = 0.1032; 0.3 uM, P=0.0001; 1 uM, P = 0.0492; 3 uM, P=0.0001; 10 uM, P=0.0001.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:43:20 UTC 2023` Edited by `admin` on `Fri Dec 15 15:43:20 UTC 2023`
Record UNII	WXE3H7W295
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

WAY-181187

Common Name

English

2-(1-((6-CHLOROIMIDAZO(2,1-B)(1,3)THIAZOL-5-YL)SULFONYL)-1H-INDOL-3-YL)ETHYLAMINE

Systematic Name

English

WAY-181,187

Code

English

Code System Code Type Description

EPA CompTox

DTXSID50204011