ISIS-449884

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 01:00:31 GMT 2025` Edited by `admin` on `Wed Apr 02 01:00:31 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	WX6O5D3SDD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISIS-449884

Code

English

DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RU-T-M5C-M5C-M5C-G-A-G-G-T-G-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA)

Preferred Name

English

Code System Code Type Description

SMS_ID

300000044090

Created by admin on Wed Apr 02 01:00:31 GMT 2025 , Edited by admin on Wed Apr 02 01:00:31 GMT 2025

PRIMARY

FDA UNII

WX6O5D3SDD

Created by admin on Wed Apr 02 01:00:31 GMT 2025 , Edited by admin on Wed Apr 02 01:00:31 GMT 2025

PRIMARY

CAS

1428588-67-3

Created by admin on Wed Apr 02 01:00:31 GMT 2025 , Edited by admin on Wed Apr 02 01:00:31 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_4-1_13	10 / 17
2'-O-Methoxyethyl ribose	1_1-1_3;1_14-1_17	7 / 17

Linkage	Site Range	Site Count
Phosporothioate	1_1-1_16	16 / 16

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ISIS-449884 SODIUM

SALT/SOLVATE -> PARENT

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					WX6O5D3SDD

ISIS-449884

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_5] [1_6] [1_7] [1_14] [1_15] [1_16]	SITE_SPECIFIC			5-METHYLCYTOSINE	6R795CQT4H