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Details

Stereochemistry ABSOLUTE
Molecular Formula C29H31N10O11S.OTc
Molecular Weight 842.587
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TECHNETIUM TC-99M ETARFOLATIDE

SMILES

O=[99Tc+3].N[C@@H](CNC(=O)CC[C@@H](NC(=O)C1=CC=C(NCC2=CNC3=NC=NC(=O)C3=N2)C=C1)C([O-])=O)C(=O)N[C@@H](CC([O-])=O)C(=O)N[C@@H](CS)C([O-])=O

InChI

InChIKey=WGPIHVKMTHWKHL-BIGPACBVSA-K
InChI=1S/C29H34N10O11S.O.Tc/c30-16(25(44)38-18(7-21(41)42)26(45)39-19(11-51)29(49)50)10-32-20(40)6-5-17(28(47)48)37-24(43)13-1-3-14(4-2-13)31-8-15-9-33-23-22(36-15)27(46)35-12-34-23;;/h1-4,9,12,16-19,31,51H,5-8,10-11,30H2,(H,32,40)(H,37,43)(H,38,44)(H,39,45)(H,41,42)(H,47,48)(H,49,50)(H,33,34,35,46);;/q;;+3/p-3/t16-,17+,18-,19-;;/m0../s1/i;;1+1

HIDE SMILES / InChI
Molecular Formula C29H31N10O11S
Molecular Weight 727.682
Charge -3
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula OTc
Molecular Weight 114.9057
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/books/NBK215133/ | https://www.iaea.org/OurWork/ST/NE/NEFW/Technical-Areas/RRS/documents /mo99/WORKINGMATERIALSmo99CM.pdf | https://www.ncbi.nlm.nih.gov/pubmed/27854401

Molybdenum-99 (99Mo, half-life = 66 h) is a parent radionuclide of a diagnostic nuclear isotope. It decays in technetium-99 m (half-life = 6 h), which is used in over 30 million procedures per year around the world. Between 95 and 98 percent of Mo-99 is currently being produced using highly enriched uranium (HEU) targets. Other medical isotopes such as iodine-131 (I-131) and xenon-133 (Xe-133) are by-products of the Mo-99 production process and will be sufficiently available if Mo-99 is available.

Approval Year

1973
98
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8429
OSTEOLITE

Approved Use

Unknown

Launch Date

1977
Diagnostic
Approved
8429
DRAXIMAGE MDP-10

Approved Use

MDP-25 (Kit for the Preparation of Technetium Tc 99m Medronate) may be used as a bone imaging agent to delineate areas of altered osteogenesis.

Launch Date

1978
PubMed

PubMed

TitleDatePubMed
Patents

Patents

20050082469
43

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:18:39 GMT 2023
Edited
by admin
on Fri Dec 15 15:18:39 GMT 2023
Record UNII
WVU7R99FQ6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TECHNETIUM TC-99M ETARFOLATIDE
Common Name English
TC-99M EC-20
Code English
TECHNETATE(3-)-99TC, (N-(4-(((2-AMINO-1,4-DIHYDRO-4-OXO-6-PTERIDINYL)METHYL)AMINO)BENZOYL)-D-.GAMMA.-GLUTAMYL-(2S)-2-(AMINO-.KAPPA.N)-.BETA.-ALANYL-L-.ALPHA.-ASPARTYL-.KAPPA.N-L-CYSTEINATO(6-)-.KAPPA.N,.KAPPA.S)OXO-, HYDROGEN (1:3), (SP-5-24)-
Common Name English
FOLATESCAN
Brand Name English
TC99M-EC20
Code English
TECHNETIUM TC-99M PTEROTETRAMIDE
Common Name English
TECHNETIUM TC 99M ETARFOLATIDE [USAN]
Common Name English
technetium (⁹⁹mTc) etarfolatide [INN]
Common Name English
Technetium (99mTc) etarfolatide [WHO-DD]
Common Name English
TECHNETIUM TC-99M 3-((N-(4-(((2-AMINO-4-OXO-3,4-DIHYDROPTERIDIN-6-YL)METHYL)AMINO)BENZOYL)-GAMMA-GLUTAMYL)AMINO)ALANYL-ALPHA-ASPARTYLCYSTEINE
USAN  
Common Name English
TECHNETIUM TC-99M EC20
Common Name English
TECHNETIUM (99MTC) ETARFOLATIDE
INN   WHO-DD  
INN  
Official Name English
TECHNETIUM TC 99M ETARFOLATIDE
USAN  
USAN  
Official Name English
TECHNETIUM TC 99M PTEROTETRAMIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2124
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
WHO-ATC V09IA08
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
Code System Code Type Description
USAN
YY-121
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
PRIMARY
CAS
479410-20-3
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
PRIMARY
EVMPD
SUB96103
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
PRIMARY
INN
9601
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
PRIMARY
PUBCHEM
135566031
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
PRIMARY
FDA UNII
WVU7R99FQ6
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
PRIMARY
SMS_ID
100000141680
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
PRIMARY
ChEMBL
CHEMBL3707391
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
PRIMARY
WIKIPEDIA
Technetium (99mTc) etarfolatide
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
PRIMARY
NCI_THESAURUS
C152525
Created by admin on Fri Dec 15 15:18:39 GMT 2023 , Edited by admin on Fri Dec 15 15:18:39 GMT 2023
PRIMARY
Related Record Type Details
Structure of ETARFOLATIDE
NON-LABELED -> LABELED
Related Record Type Details
Structure of TECHNETIUM TC-99M ETARFOLATIDE
ACTIVE MOIETY
Structure of TECHNETIUM TC-99M
ACTIVE MOIETY
NIH
NCATS
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