U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C41H68O14
Molecular Weight 784.9702
Optical Activity UNSPECIFIED
Defined Stereocenters 21 / 21
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ASTRAGALOSIDE III

SMILES

CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]2[C@@H](O)C[C@@]3(C)[C@@H]4C[C@H](O)[C@@H]5[C@]6(C[C@@]46CC[C@]23C)CC[C@H](O[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C5(C)C

InChI

InChIKey=FVFSMBDVZVUETN-BQAOMNQWSA-N
InChI=1S/C41H68O14/c1-35(2)24(53-34-30(26(46)21(45)17-51-34)54-33-29(49)28(48)27(47)22(16-42)52-33)9-11-41-18-40(41)13-12-37(5)32(39(7)10-8-25(55-39)36(3,4)50)20(44)15-38(37,6)23(40)14-19(43)31(35)41/h19-34,42-50H,8-18H2,1-7H3/t19-,20-,21+,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34-,37+,38-,39+,40-,41+/m0/s1

HIDE SMILES / InChI
Molecular Formula C41H68O14
Molecular Weight 784.9702
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 21 / 21
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Astragaloside III is a naturally occurring triterpene saponin compound isolated from Radix Astragali, which has been demonstrated to have anti-gastric ulcer, immunomodulatory and antitumor effects.

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Determination of astragaloside III in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study.
2016-02
Development and Validation of a Rapid and Simple UPLC-ESI-MS Method for Pharmacokinetics and Tissue Distribution of Astragaloside III in Rats.
2015-08-03
Simultaneous determination of nineteen major components in Qi She Pill by ultra-high-performance liquid chromatography-tandem mass spectrometry.
2014-10
Patents

Patents

US8168596 B2
1
US8197860 B2
1

Sample Use Guides

In Vivo Use Guide
In a preclinical study, mice were given Astragaloside III at a dose of 10 mg/kg or 20 mg/kg i.p. every 2 days.
Route of Administration: Intraperitoneal
In Vitro Use Guide
In a cell viability assay, MCF-7 cells (6000 cells) were seeded into 96-well plates for 24/48 hours in presence of 10, 50, and 100 ng/ml Astragaloside III, respectively.
Substance Class Chemical
Created
by admin
on Tue Apr 01 16:20:57 GMT 2025
Edited
by admin
on Tue Apr 01 16:20:57 GMT 2025
Record UNII
WVP53009FC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ASTRAGALOSIDE III (CONSTITUENT OF ASTRAGALUS) [DSC]
Preferred Name English
ASTRAGALOSIDE III
Common Name English
.BETA.-D-XYLOPYRANOSIDE, (3.BETA.,6.ALPHA.,16.BETA.,20R,24S)-20,24-EPOXY-6,16,25-TRIHYDROXY-9,19-CYCLOLANOSTAN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-
Systematic Name English
Code System Code Type Description
CAS
84687-42-3
Created by admin on Tue Apr 01 16:20:57 GMT 2025 , Edited by admin on Tue Apr 01 16:20:57 GMT 2025
PRIMARY
EPA CompTox
DTXSID40331663
Created by admin on Tue Apr 01 16:20:57 GMT 2025 , Edited by admin on Tue Apr 01 16:20:57 GMT 2025
PRIMARY
FDA UNII
WVP53009FC
Created by admin on Tue Apr 01 16:20:57 GMT 2025 , Edited by admin on Tue Apr 01 16:20:57 GMT 2025
PRIMARY
PUBCHEM
441905
Created by admin on Tue Apr 01 16:20:57 GMT 2025 , Edited by admin on Tue Apr 01 16:20:57 GMT 2025
PRIMARY
Related Record Type Details
Astragalus mongholicus root
PARENT -> CONSTITUENT ALWAYS PRESENT
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966