Ruxolitinib, S-

N#CC[C@@H](C1CCCC1)N2C=C(C=N2)C3=NC=NC4=C3C=CN4

InChIKey=HFNKQEVNSGCOJV-HNNXBMFYSA-N

InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m0/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Substance Class	Chemical Created by `admin` on `Wed Apr 02 21:25:28 GMT 2025` Edited by `admin` on `Wed Apr 02 21:25:28 GMT 2025`
Record UNII	WVA83G6MCW
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

INCB-18424

Preferred Name

English

Ruxolitinib, S-

Common Name

English

1H-Pyrazole-1-propanenitrile, ?-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (?S)

Systematic Name

English

(?S)-?-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile

Systematic Name

English

(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

Systematic Name

English

(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile

Systematic Name

English

S-Ruxolitinib

Common Name

English

Code System Code Type Description

FDA UNII

WVA83G6MCW