PERAFENSINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H19N3
Molecular Weight	289.3743
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1CN(CCN1)C2=NC(C3=CC=CC=C3)=C4C=CC=CC4=C2

InChI

InChIKey=BHHDTFRLKOTSKW-UHFFFAOYSA-N

InChI=1S/C19H19N3/c1-2-6-15(7-3-1)19-17-9-5-4-8-16(17)14-18(21-19)22-12-10-20-11-13-22/h1-9,14,20H,10-13H2

HIDE SMILES / InChI

Molecular Formula	C19H19N3
Molecular Weight	289.3743
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9134007 | DOI: 10.1016/S0065-7743(08)60487-X | https://psycnet.apa.org/record/1987-18076-001 | (1986) Progress in Medicinal Chemistry, page 147, retrieved from: https://books.google.ru/books?id=gmhcIEQ2UzIC | (1987) Excerpta medica. Section 48: Gastroenterology, page 87, retrieved from: https://books.google.ru/books?id=TFSaAAAAIAAJ

Perafensine is an isoquinoline derivative shown to be active in tests predictive of antidepressant activity. Perafensine is a potent antagonist of reserpine-induced effects and inhibits norepinephrine uptake into rat hypothalamic synaptosomes. Perafensine induced the biosynthesis of microsomal drug-metabolizing enzymes – in treated rats methylayapanine O-demethylase, ethoxycoumarin O-deethylase and cytochrome P-450 contents were increased and ketamine N-demethylase was decreased.

Approval Year

PubMed

Title	Date	PubMed
Selective induction of phase II drug metabolizing enzyme activities by quinolines and isoquinolines.	1997 Mar 14	9134007

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:13:02 GMT 2023` Edited by `admin` on `Sat Dec 16 17:13:02 GMT 2023`
Record UNII	WU6989IN6X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PERAFENSINE

Official Name

English

1-PHENYL-3-(1-PIPERAZINYL)ISOQUINOLINE

Systematic Name

English

perafensine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197