Onzemipgene Parvec

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 21:17:22 GMT 2025` Edited by `admin` on `Wed Apr 02 21:17:22 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	RECOMBINANT VIRUS
Source Materials State	LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family	Parvoviridae
Organism Genus	Dependoparvovirus
Organism Species	adeno-associated dependoparvovirus a
Infraspecific Type	RECOMBINANT VECTOR
Infraspecific Name	rAAV2-sCD59
Part	whole
Record UNII	WU56BNE7AU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AAVCAGsCD59

Preferred Name

English

Onzemipgene Parvec

Official Name

English

recombinant non-replicating adeno-associated virus serotype 2 (rAAV2) vector, encoding a truncated soluble form of human CD59 (sCD59, membrane-independent human CD59) under control of the CAG promoter (cytomegalovirus (CMV) enhancer / chicken betaactin (

Common Name

English

onzemipgene parvec [INN]

Common Name

English

Code System Code Type Description

FDA UNII

WU56BNE7AU

Created by admin on Wed Apr 02 21:17:22 GMT 2025 , Edited by admin on Wed Apr 02 21:17:22 GMT 2025

PRIMARY

INN

13190

Created by admin on Wed Apr 02 21:17:22 GMT 2025 , Edited by admin on Wed Apr 02 21:17:22 GMT 2025

PRIMARY

CAS

2269489-41-8

Created by admin on Wed Apr 02 21:17:22 GMT 2025 , Edited by admin on Wed Apr 02 21:17:22 GMT 2025

PRIMARY

Related Record Type Details


					7EEM99PZE5

CD59 glycoprotein

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					WU56BNE7AU

Onzemipgene Parvec

ACTIVE MOIETY

Comments:

gene therapy (macular degeneration)

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Onzemipgene parvec transgene insert encoding a truncated soluble form of human CD59	XR2CZD2UT3