Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C21H24N2O2 |
Molecular Weight | 336.4275 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[N@]3CCC4=C(NC5=CC=CC=C45)[C@](C1)(C(=O)OC)[C@@]3([H])C(CC)=C2
InChI
InChIKey=CMKFQVZJOWHHDV-NQZBTDCJSA-N
InChI=1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1
Molecular Formula | C21H24N2O2 |
Molecular Weight | 336.4275 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/23532933Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/13641069 | https://www.ncbi.nlm.nih.gov/pubmed/23532933
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23532933
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/13641069 | https://www.ncbi.nlm.nih.gov/pubmed/23532933
Catharanthine is a terpene indole alkaloid produced by the medicinal plant Catharanthus roseus. Catharanthine is derived from strictosidine, but the exact mechanism by which this happens is currently unknown. Catharanthine is one of the two precursors that form vinblastine, the other being vindoline.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL3108632 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25052206 |
0.9 µM [IC50] | ||
Target ID: CHEMBL6007 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25052206 |
9000.0 nM [EC50] | ||
Target ID: CHEMBL4794 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25052206 |
20.0 µM [EC50] | ||
Target ID: CHEMBL2095177 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23532933 |
220.0 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23532933
Intravenous administration of catharanthine (0.5–20 mg/kg) to anesthetized rats induced rapid, dose-dependent decreases in blood pressure, heart rate, left ventricular blood pressure, cardiac contractility, and the slope of the end-systolic pressure-volume relationship curve.
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23532933
Catharanthine evoked concentrationdependent decreases in endothelium-independent tonic responses of aortic rings to phenylephrine (PE) and KCl (IC50 = 5 28 uM for PE and IC50 =5 34 mM for KCl) and of thirdorder branches of the small mesenteric artery (IC50 = 3 mM for PE and IC50 = 6 mM for KCl)
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:45:19 GMT 2023
by
admin
on
Fri Dec 15 15:45:19 GMT 2023
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Record UNII |
WT0YJV846J
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Record Status |
Validated (UNII)
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Record Version |
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2468-21-5
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142675
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m3175
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DTXSID80947621
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5458190
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219-586-6
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WT0YJV846J
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Catharanthine
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