K-832

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H19ClN2OS
Molecular Weight	418.938
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSC1=CC=C(C=C1)C2=NN(CC3=CC=CC=C3)C(=O)C=C2C4=CC=C(Cl)C=C4

InChI

InChIKey=HEUAVAATAFEENP-UHFFFAOYSA-N

InChI=1S/C24H19ClN2OS/c1-29-21-13-9-19(10-14-21)24-22(18-7-11-20(25)12-8-18)15-23(28)27(26-24)16-17-5-3-2-4-6-17/h2-15H,16H2,1H3

HIDE SMILES / InChI

Molecular Formula	C24H19ClN2OS
Molecular Weight	418.938
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Enhancement of dissolution rate and oral absorption of a poorly water-soluble drug, K-832, by adsorption onto porous silica using supercritical carbon dioxide.	2010-10	20603215

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:46:31 GMT 2025` Edited by `admin` on `Wed Apr 02 09:46:31 GMT 2025`
Record UNII	WR9SVX36QF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

K 832

Preferred Name

English

K-832

Common Name

English

3(2H)-PYRIDAZINONE, 5-(4-CHLOROPHENYL)-6-(4-(METHYLTHIO)PHENYL)-2-(PHENYLMETHYL)-

Systematic Name

English

2-BENZYL-5-(4-CHLOROPHENYL)-6-(4-METHYLSULFANYLPHENYL)PYRIDAZIN-3-ONE

Systematic Name

English

5-(4-CHLOROPHENYL)-6-(4-(METHYLTHIO)PHENYL)-2-(PHENYLMETHYL)-3(2H)-PYRIDAZINONE

Systematic Name

English

Code System Code Type Description

PUBCHEM

9844960

Created by admin on Wed Apr 02 09:46:31 GMT 2025 , Edited by admin on Wed Apr 02 09:46:31 GMT 2025

PRIMARY

CAS

225666-85-3

Created by admin on Wed Apr 02 09:46:31 GMT 2025 , Edited by admin on Wed Apr 02 09:46:31 GMT 2025

PRIMARY

SMS_ID

300000050555

Created by admin on Wed Apr 02 09:46:31 GMT 2025 , Edited by admin on Wed Apr 02 09:46:31 GMT 2025

PRIMARY

FDA UNII

WR9SVX36QF

Created by admin on Wed Apr 02 09:46:31 GMT 2025 , Edited by admin on Wed Apr 02 09:46:31 GMT 2025

PRIMARY

Related Record Type Details


					WR9SVX36QF

K-832

ACTIVE MOIETY

Comments:

Results of an in vivo absorption test showed that the area under the plasma concentration-time curve and peak concentration of K-832-silica scCO(2) were 8.3- and 13.3-fold greater than those of K-832 crystal, whereas the corresponding values of K-832-silica DCM were 5.0- and 8.3-fold greater than those of K-832 crystal.

Amount: