U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 19:55:56 GMT 2023
Edited
by admin
on Sat Dec 16 19:55:56 GMT 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE ATTENUATED GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Name CD4+ and CD8+ enriched T lymphocytes
Record UNII
WQD5K35YZT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Anitocabtagene Autoleucel
INN  
Official Name English
Autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) comprising a three-helix bundle D domain polypep
Common Name English
anitocabtagene autoleucel [INN]
Common Name English
Code System Code Type Description
FDA UNII
WQD5K35YZT
Created by admin on Sat Dec 16 19:55:56 GMT 2023 , Edited by admin on Sat Dec 16 19:55:56 GMT 2023
PRIMARY
INN
12425
Created by admin on Sat Dec 16 19:55:56 GMT 2023 , Edited by admin on Sat Dec 16 19:55:56 GMT 2023
PRIMARY
NCI_THESAURUS
C199003
Created by admin on Sat Dec 16 19:55:56 GMT 2023 , Edited by admin on Sat Dec 16 19:55:56 GMT 2023
PRIMARY
Related Record Type Details
TARGET->CYTOTOXIC T-CELL
CONSTITUENT ALWAYS PRESENT -> PARENT
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CULTURE EXPANSION BIOLOGICAL HUMAN INTERLEUKIN-2 FNO32LO217
LENTIVIRAL TRANSFECTION TRANSFECTION BIOLOGICAL Anitocabtagene autoleucel lentiviral vector GC3PDT9JAS
CULTURE ACTIVATOR BIOLOGICAL UNSPECIFIED SUBSTANCE 4e4ac683
CULTURE EXPANSION BIOLOGICAL ALBUMIN HUMAN, RECOMBINANT C37E62Z9JZ

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN Anitocabtagene autoleucel expressed CAR sequence U9R9QBC9RG
INSERTED GENE EXPRESSION VECTOR Anitocabtagene autoleucel transgene insert 7Q929V79JB