Anitocabtagene Autoleucel

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 17:45:57 GMT 2025` Edited by `admin` on `Wed Apr 02 17:45:57 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE ATTENUATED GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Name	cd4+ and cd8+ enriched t lymphocytes
Record UNII	WQD5K35YZT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ANITOCABTAGENE AUTOLEUCEL [USAN]

Preferred Name

English

Anitocabtagene Autoleucel

Official Name

English

CART-ddBCMA

Common Name

English

Autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) comprising a three-helix bundle D domain polypep

Common Name

English

anitocabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

USAN

MN-20

Created by admin on Wed Apr 02 17:45:57 GMT 2025 , Edited by admin on Wed Apr 02 17:45:57 GMT 2025

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FDA UNII

WQD5K35YZT

Created by admin on Wed Apr 02 17:45:57 GMT 2025 , Edited by admin on Wed Apr 02 17:45:57 GMT 2025

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INN

12425

Created by admin on Wed Apr 02 17:45:57 GMT 2025 , Edited by admin on Wed Apr 02 17:45:57 GMT 2025

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SMS_ID

300000052715

Created by admin on Wed Apr 02 17:45:57 GMT 2025 , Edited by admin on Wed Apr 02 17:45:57 GMT 2025

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NCI_THESAURUS

C199003

Created by admin on Wed Apr 02 17:45:57 GMT 2025 , Edited by admin on Wed Apr 02 17:45:57 GMT 2025

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Anitocabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL		HUMAN INTERLEUKIN-2	FNO32LO217
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL		Anitocabtagene autoleucel lentiviral vector	GC3PDT9JAS
CULTURE	ACTIVATOR	BIOLOGICAL		ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M
CULTURE	EXPANSION	BIOLOGICAL		ALBUMIN HUMAN, RECOMBINANT	C37E62Z9JZ

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Anitocabtagene autoleucel expressed CAR sequence	U9R9QBC9RG
INSERTED GENE EXPRESSION VECTOR					Anitocabtagene autoleucel transgene insert	7Q929V79JB