Anitocabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:55:56 GMT 2023` Edited by `admin` on `Sat Dec 16 19:55:56 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE ATTENUATED GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Name	CD4+ and CD8+ enriched T lymphocytes
Record UNII	WQD5K35YZT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Anitocabtagene Autoleucel

Official Name

English

Autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) comprising a three-helix bundle D domain polypep

Common Name

English

anitocabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

FDA UNII

WQD5K35YZT

Created by admin on Sat Dec 16 19:55:56 GMT 2023 , Edited by admin on Sat Dec 16 19:55:56 GMT 2023

PRIMARY

INN

12425

Created by admin on Sat Dec 16 19:55:56 GMT 2023 , Edited by admin on Sat Dec 16 19:55:56 GMT 2023

PRIMARY

NCI_THESAURUS

C199003

Created by admin on Sat Dec 16 19:55:56 GMT 2023 , Edited by admin on Sat Dec 16 19:55:56 GMT 2023

PRIMARY

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INTERFERON GAMMA

CONSTITUENT ALWAYS PRESENT -> PARENT

Amount:

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Anitocabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Anitocabtagene autoleucel lentiviral vector	GC3PDT9JAS
CULTURE	ACTIVATOR	BIOLOGICAL	UNSPECIFIED SUBSTANCE	4e4ac683
CULTURE	EXPANSION	BIOLOGICAL	ALBUMIN HUMAN, RECOMBINANT	C37E62Z9JZ

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Anitocabtagene autoleucel expressed CAR sequence	U9R9QBC9RG
INSERTED GENE EXPRESSION VECTOR					Anitocabtagene autoleucel transgene insert	7Q929V79JB