PATISIRAN SODIUM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 13:45:03 UTC 2023` Edited by `admin` on `Sat Dec 16 13:45:03 UTC 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	WO0YM16LKG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PATISIRAN SODIUM

Common Name

English

RNA, (A-U-G-G-A-A-UM-A-C-U-C-U-U-G-G-U-UM-A-C-DT-DT), COMPLEX WITH RNA (G-UM-A-A-CM-CM-A-A-G-A-G-UM-A-UM-UM-CM-CM-A-UM-DT-DT), SODIUM SALT (1:1:40)

Systematic Name

English

ONPATTRO

Brand Name

English

Patisiran sodium [WHO-DD]

Common Name

English

PATISIRAN SODIUM [JAN]

Common Name

English

PATISIRAN SODIUM [ORANGE BOOK]

Common Name

English

PATISIRAN SODIUM [MI]

Common Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/11/857

Created by admin on Sat Dec 16 13:45:03 UTC 2023 , Edited by admin on Sat Dec 16 13:45:03 UTC 2023

Code System Code Type Description

EPA CompTox

DTXSID601027891

Created by admin on Sat Dec 16 13:45:03 UTC 2023 , Edited by admin on Sat Dec 16 13:45:03 UTC 2023

PRIMARY

DRUG BANK

DBSALT002783

Created by admin on Sat Dec 16 13:45:03 UTC 2023 , Edited by admin on Sat Dec 16 13:45:03 UTC 2023

PRIMARY

FDA UNII

WO0YM16LKG

Created by admin on Sat Dec 16 13:45:03 UTC 2023 , Edited by admin on Sat Dec 16 13:45:03 UTC 2023

PRIMARY

RXCUI

2053491

Created by admin on Sat Dec 16 13:45:03 UTC 2023 , Edited by admin on Sat Dec 16 13:45:03 UTC 2023

PRIMARY

MERCK INDEX

m12092

Created by admin on Sat Dec 16 13:45:03 UTC 2023 , Edited by admin on Sat Dec 16 13:45:03 UTC 2023

PRIMARY

CAS

1386913-72-9

Created by admin on Sat Dec 16 13:45:03 UTC 2023 , Edited by admin on Sat Dec 16 13:45:03 UTC 2023

PRIMARY

DAILYMED

WO0YM16LKG

Created by admin on Sat Dec 16 13:45:03 UTC 2023 , Edited by admin on Sat Dec 16 13:45:03 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_20-1_21;2_20-2_21	4 / 42
2'-O-Methyl-Ribose	1_2;1_5-1_6;1_12;1_14-1_17;1_19;2_7;2_17	11 / 42
D-Ribose (RNA)	1_1;1_3-1_4;1_7-1_11;1_13;1_18;2_1-2_6;2_8-2_16;2_18-2_19	27 / 42

Linkage	Site Range	Site Count
	1_2-1_21;2_2-2_21	40 / 40

Related Record Type Details


					50FKX8CB2Y

PATISIRAN

PARENT -> SALT/SOLVATE

Related Record Type Details


					50FKX8CB2Y

PATISIRAN

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_2] [1_12] [1_14] [1_15] [1_19] [2_7] [2_17]				2'-O-METHYLURIDINE	399VZB6TMB
NUCLEOSIDE_SUBSTITUTION	[1_5] [1_6] [1_16] [1_17]				2'-O-METHYLCYTIDINE	5XD9IH2G27