LERIGLITAZONE HYDROCHLORIDE

Investigational

Description

Hydroxypioglitazone (M-IV) is an active metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone. Experiments in vitro have shown that hydroxypioglitazone was more efficient than the parent drug in stimulating lipid synthesis.

Approval Year

PubMed

Title	Date	PubMed
Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone.	1996 Dec 20	8978836
Development and validation of highly selective and robust method for simultaneous estimation of pioglitazone, hydroxypioglitazone and metformin in human plasma by LC-MS/MS: application to a pharmacokinetic study.	2013 Jul 1	23732843
A validated liquid chromatography tandem mass spectrometry method for simultaneous determination of pioglitazone, hydroxypioglitazone, and ketopioglitazone in human plasma and its application to a clinical study.	2014 Oct 15	25195022

Substance Class	Concept
Record UNII	WN9K42SAM6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LERIGLITAZONE HYDROCHLORIDE

Official Name

English

ALL-AMBO-5-((4-(2-(5-(1-HYDROXYETHYL)PYRIDIN-2-YL)ETHOXY)PHENYL)METHYL)-1,3-THIAZOLE-2,4(3H,5H)-DIONE HYDROCLORIDE (1:1)

Common Name

English

LERIGLITAZONE HYDROCHLORIDE [USAN]

Common Name

English

2,4-THIAZOLIDINEDIONE, 5-((4-(2-(5-(1-HYDROXYETHYL)-2-PYRIDINYL)ETHOXY)PHENYL)METHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

2,4-THIAZOLIDINEDIONE, 5-((4-(2-(5-(1-HYDROXYETHYL)-2-PYRIDINYL)ETHOXY)PHENYL)METHYL)-, MONOHYDROCHLORIDE

Systematic Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/16/1770

Created by admin on Mon Oct 21 20:54:50 UTC 2019 , Edited by admin on Mon Oct 21 20:54:50 UTC 2019

Code System Code Type Description

CAS

146062-46-6

Created by admin on Mon Oct 21 20:54:50 UTC 2019 , Edited by admin on Mon Oct 21 20:54:50 UTC 2019

PRIMARY

EVMPD

SUB196366

Created by admin on Mon Oct 21 20:54:50 UTC 2019 , Edited by admin on Mon Oct 21 20:54:50 UTC 2019

PRIMARY

PUBCHEM

86748889

Created by admin on Mon Oct 21 20:54:50 UTC 2019 , Edited by admin on Mon Oct 21 20:54:50 UTC 2019

PRIMARY

This is a non-substance concept

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