LERIGLITAZONE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H20N2O4S.ClH
Molecular Weight	408.899
Optical Activity	( + / - )
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LERIGLITAZONE HYDROCHLORIDE

Structure Search

SMILES

Cl.CC(O)C1=CC=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C1

InChI

InChIKey=SBHOQYCDAHAMDW-UHFFFAOYSA-N

InChI=1S/C19H20N2O4S.ClH/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17;/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24);1H

HIDE SMILES / InChI

Molecular Formula	C19H20N2O4S
Molecular Weight	372.438
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8978836

Hydroxypioglitazone (M-IV) is an active metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone. Experiments in vitro have shown that hydroxypioglitazone was more efficient than the parent drug in stimulating lipid synthesis.

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Sat Dec 16 14:28:09 GMT 2023` Edited by `admin` on `Sat Dec 16 14:28:09 GMT 2023`
Record UNII	WN9K42SAM6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LERIGLITAZONE HYDROCHLORIDE

Official Name

English

ALL-AMBO-5-((4-(2-(5-(1-HYDROXYETHYL)PYRIDIN-2-YL)ETHOXY)PHENYL)METHYL)-1,3-THIAZOLE-2,4(3H,5H)-DIONE HYDROCLORIDE (1:1)

Common Name

English

LERIGLITAZONE HYDROCHLORIDE [USAN]

Common Name

English

HYDROXYPIOGLITAZONE HYDROCHLORIDE

Common Name

English

2,4-THIAZOLIDINEDIONE, 5-((4-(2-(5-(1-HYDROXYETHYL)-2-PYRIDINYL)ETHOXY)PHENYL)METHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

2,4-THIAZOLIDINEDIONE, 5-((4-(2-(5-(1-HYDROXYETHYL)-2-PYRIDINYL)ETHOXY)PHENYL)METHYL)-, MONOHYDROCHLORIDE

Systematic Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/16/1770