DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/8978836
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8978836
Hydroxypioglitazone (M-IV) is an active metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone. Experiments in vitro have shown that hydroxypioglitazone was more efficient than the parent drug in stimulating lipid synthesis.
Approval Year
PubMed
Title | Date | PubMed |
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Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone. | 1996 Dec 20 |
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Development and validation of highly selective and robust method for simultaneous estimation of pioglitazone, hydroxypioglitazone and metformin in human plasma by LC-MS/MS: application to a pharmacokinetic study. | 2013 Jul 1 |
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A validated liquid chromatography tandem mass spectrometry method for simultaneous determination of pioglitazone, hydroxypioglitazone, and ketopioglitazone in human plasma and its application to a clinical study. | 2014 Oct 15 |
Substance Class |
Concept
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Record UNII |
WN9K42SAM6
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Record Status |
Validated (UNII)
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EU-Orphan Drug |
EU/3/16/1770
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146062-46-6
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SUB196366
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86748889
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C174935
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WN9K42SAM6
Created by
admin on Sat Jun 26 03:38:57 UTC 2021 , Edited by admin on Sat Jun 26 03:38:57 UTC 2021
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PRIMARY |
This is a non-substance concept
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |
This is a non-substance concept