Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C28H26N7.CH3O3S |
| Molecular Weight | 555.651 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CS([O-])(=O)=O.CC[N+]1=C(C2=CC=CC=C2)C3=C(C=CC(=C3)\N=N\NC4=CC=CC(=C4)C(N)=N)C5=C1C=C(N)C=C5
InChI
InChIKey=SNMWNEQGAIYVQF-UHFFFAOYSA-N
InChI=1S/C28H25N7.CH4O3S/c1-2-35-26-16-20(29)11-13-24(26)23-14-12-22(17-25(23)27(35)18-7-4-3-5-8-18)33-34-32-21-10-6-9-19(15-21)28(30)31;1-5(2,3)4/h3-17,29H,2H2,1H3,(H4,30,31,32,33);1H3,(H,2,3,4)
| Molecular Formula | C28H25N7 |
| Molecular Weight | 459.545 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
| Molecular Formula | CH4O3S |
| Molecular Weight | 96.106 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia. | 1988 Jun |
|
| Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs. | 1992 Sep |
|
| New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. | 1995 Nov 24 |
|
| Drug-resistant Trypanosoma congolense in naturally infected donkeys in north Omo Zone, southern Ethiopia. | 2001 Aug 31 |
|
| The in vitro effects of isometamidium chloride (Samorin) on the piscine hemoflagellate Cryptobia salmositica (Kinetoplastida, Bodonina). | 2001 Feb |
|
| Financial implications of rearing sheep and goats under natural trypanosomosis challenge at Galana ranch, Kenya. | 2002 Nov |
|
| Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda. | 2002 Oct |
|
| Field studies of drug-resistant cattle trypanosomes in Kénédougou Province, Burkina Faso. | 2003 Apr |
|
| Knowledge and attitudes of cattle owners regarding trypanosomosis control in tsetse-infested areas of Uganda. | 2004 Dec |
|
| Trypanocidal drug resistance in eastern province of Zambia. | 2004 Jan 30 |
|
| RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate. | 2004 May-Jun |
|
| Protective efficacy of isometamidium chloride and diminazene aceturate against natural Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population in Uganda. | 2004 Sep |
|
| Evaluation of isometamidium levels in the serum of sheep and goats after prophylactic treatment against trypanosomosis. | 2004 Sep |
|
| Trypanocidal failure suggested by PCR results in cattle field samples. | 2004 Sep |
|
| The susceptibility of Trypanosoma congolense isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride. | 2005 Dec |
|
| Identification of a genetic marker for isometamidium chloride resistance in Trypanosoma congolense. | 2005 Feb |
|
| Detection of trypanosomes in small ruminants and pigs in western Kenya: important reservoirs in the epidemiology of sleeping sickness? | 2005 Jul 14 |
|
| RNA aptamers as potential pharmaceuticals against infections with African trypanosomes. | 2006 |
|
| Rapid identification of isometamidium-resistant stocks of Trypanosoma b. brucei by PCR-RFLP. | 2006 Aug |
|
| Metabolism of isometamidium in hepatocytes isolated from control and inducer-treated rats. | 2006 Dec |
|
| Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania. | 2006 Feb |
|
| The transmissibility of Trypanosoma congolense seems to be associated with its level of resistance to isometamidium chloride. | 2006 Feb 18 |
|
| Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test. | 2006 Jan |
|
| Effect of isometamidium chloride treatment on susceptibility of tsetse flies (Diptera: Glossinidae) to trypanosome infections. | 2006 May |
|
| Point mutations in mitochondrial topoisomerase enzymes of Trypanosoma congolense are not involved in isometamidium resistance. | 2007 Jan |
|
| Absence of correlation between karyotype profiles of Trypanosoma congolense and resistance to isometamidium chloride. | 2007 Jul 20 |
|
| Health management of horses under high challenge from trypanosomes: a case study from Serengeti, Tanzania. | 2008 Jul 4 |
|
| Immunobiology of African trypanosomes: need of alternative interventions. | 2010 |
|
| Diverse effects on mitochondrial and nuclear functions elicited by drugs and genetic knockdowns in bloodstream stage Trypanosoma brucei. | 2010 May 4 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:22:30 GMT 2023
by
admin
on
Fri Dec 15 15:22:30 GMT 2023
|
| Record UNII |
WN91WG5WNT
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID40957004
Created by
admin on Fri Dec 15 15:22:30 GMT 2023 , Edited by admin on Fri Dec 15 15:22:30 GMT 2023
|
PRIMARY | |||
|
215372
Created by
admin on Fri Dec 15 15:22:30 GMT 2023 , Edited by admin on Fri Dec 15 15:22:30 GMT 2023
|
PRIMARY | |||
|
WN91WG5WNT
Created by
admin on Fri Dec 15 15:22:30 GMT 2023 , Edited by admin on Fri Dec 15 15:22:30 GMT 2023
|
PRIMARY | |||
|
35628-03-6
Created by
admin on Fri Dec 15 15:22:30 GMT 2023 , Edited by admin on Fri Dec 15 15:22:30 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |