Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C28H26N7.CH3O3S |
| Molecular Weight | 555.651 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CS([O-])(=O)=O.CC[N+]1=C(C2=CC=CC=C2)C3=CC(=CC=C3C4=C1C=C(N)C=C4)\N=N\NC5=CC(=CC=C5)C(N)=N
InChI
InChIKey=SNMWNEQGAIYVQF-UHFFFAOYSA-N
InChI=1S/C28H25N7.CH4O3S/c1-2-35-26-16-20(29)11-13-24(26)23-14-12-22(17-25(23)27(35)18-7-4-3-5-8-18)33-34-32-21-10-6-9-19(15-21)28(30)31;1-5(2,3)4/h3-17,29H,2H2,1H3,(H4,30,31,32,33);1H3,(H,2,3,4)
| Molecular Formula | C28H25N7 |
| Molecular Weight | 459.545 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
| Molecular Formula | CH4O3S |
| Molecular Weight | 96.106 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The killing of African trypanosomes by ethidium bromide. | 2010-12-16 |
|
| Dyes, trypanosomiasis and DNA: a historical and critical review. | 2010-12 |
|
| Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin. | 2010-09-28 |
|
| Diverse effects on mitochondrial and nuclear functions elicited by drugs and genetic knockdowns in bloodstream stage Trypanosoma brucei. | 2010-05-04 |
|
| Immunology and cell biology of parasitic diseases. | 2010 |
|
| Immunobiology of African trypanosomes: need of alternative interventions. | 2010 |
|
| Immunological and therapeutic strategies against salmonid cryptobiosis. | 2010 |
|
| Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal. | 2009-09-29 |
|
| Advancing drug innovation for neglected diseases-criteria for lead progression. | 2009-08-25 |
|
| Health management of horses under high challenge from trypanosomes: a case study from Serengeti, Tanzania. | 2008-07-04 |
|
| Does isometamidium chloride treatment protect tsetse flies from trypanosome infections during SIT campaigns? | 2008-06 |
|
| Molecular tools for the rapid detection of drug resistance in animal trypanosomes. | 2008-05 |
|
| Assessment of the occurrence of trypanocidal drug resistance in trypanosomes of naturally infected cattle in the Adamaoua region of Cameroon using the standard mouse test and molecular tools. | 2008-05 |
|
| Prevalence of bovine trypanosomosis and trypanocidal drug sensitivity studies on Trypanosoma congolense in Wolyta and Dawero zones of southern Ethiopia. | 2008-03-25 |
|
| The history of African trypanosomiasis. | 2008-02-12 |
|
| Development and validation of an improved HPLC method for the control of potentially counterfeit isometamidium products. | 2008-01-07 |
|
| Absence of correlation between karyotype profiles of Trypanosoma congolense and resistance to isometamidium chloride. | 2007-07-20 |
|
| Occurrence of multiple drug resistance in Trypanosoma brucei rhodesiense isolated from sleeping sickness patients. | 2007-03 |
|
| Point mutations in mitochondrial topoisomerase enzymes of Trypanosoma congolense are not involved in isometamidium resistance. | 2007-01 |
|
| Metabolism of isometamidium in hepatocytes isolated from control and inducer-treated rats. | 2006-12 |
|
| Response of Trypanosoma vivax and Trypanosoma congolense in zebu cattle in North Cameroon to prophylactic treatment with two formulations of isometamidium. | 2006-09-15 |
|
| Rapid identification of isometamidium-resistant stocks of Trypanosoma b. brucei by PCR-RFLP. | 2006-08 |
|
| Effect of isometamidium chloride treatment on susceptibility of tsetse flies (Diptera: Glossinidae) to trypanosome infections. | 2006-05 |
|
| The transmissibility of Trypanosoma congolense seems to be associated with its level of resistance to isometamidium chloride. | 2006-02-18 |
|
| Drug-resistance of Trypanosoma b. rhodesiense isolates from Tanzania. | 2006-02 |
|
| Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test. | 2006-01 |
|
| RNA aptamers as potential pharmaceuticals against infections with African trypanosomes. | 2006 |
|
| The susceptibility of Trypanosoma congolense isolated in Zambézia Province, Mozambique, to isometamidium chloride, diminazene aceturate and homidium chloride. | 2005-12 |
|
| Detection of trypanosomes in small ruminants and pigs in western Kenya: important reservoirs in the epidemiology of sleeping sickness? | 2005-07-14 |
|
| Identification of a genetic marker for isometamidium chloride resistance in Trypanosoma congolense. | 2005-02 |
|
| Knowledge and attitudes of cattle owners regarding trypanosomosis control in tsetse-infested areas of Uganda. | 2004-12 |
|
| Protective efficacy of isometamidium chloride and diminazene aceturate against natural Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population in Uganda. | 2004-09 |
|
| Evaluation of isometamidium levels in the serum of sheep and goats after prophylactic treatment against trypanosomosis. | 2004-09 |
|
| Trypanocidal failure suggested by PCR results in cattle field samples. | 2004-09 |
|
| Application of field methods to assess isometamidium resistance of trypanosomes in cattle in western Ethiopia. | 2004-04 |
|
| Trypanocidal drug resistance in eastern province of Zambia. | 2004-01-30 |
|
| Cryptobia (Trypanoplasma) salmositica and salmonid cryptobiosis. | 2004-01-09 |
|
| RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate. | 2003-10-22 |
|
| Field studies of drug-resistant cattle trypanosomes in Kénédougou Province, Burkina Faso. | 2003-04 |
|
| Monitoring the correct use of isometamidium by farmers and veterinary assistants in Eastern Province of Zambia using the isometamidium-ELISA. | 2002-12-11 |
|
| Financial implications of rearing sheep and goats under natural trypanosomosis challenge at Galana ranch, Kenya. | 2002-11 |
|
| Growth and mortality in sheep and goats under high tsetse challenge in Kenya. | 2002-11 |
|
| A competitive enzyme-linked immunosorbent assay for diminazene. | 2002-11 |
|
| Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda. | 2002-10 |
|
| Drug-resistant Trypanosoma congolense in naturally infected donkeys in north Omo Zone, southern Ethiopia. | 2001-08-31 |
|
| Cryptobiosis and its control in North American fishes. | 2001-05-01 |
|
| Transporters in African trypanosomes: role in drug action and resistance. | 2001-05-01 |
|
| New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. | 1995-11-24 |
|
| Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs. | 1992-09 |
|
| Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia. | 1988-06 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:55:36 GMT 2025
by
admin
on
Mon Mar 31 17:55:36 GMT 2025
|
| Record UNII |
WN91WG5WNT
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID40957004
Created by
admin on Mon Mar 31 17:55:36 GMT 2025 , Edited by admin on Mon Mar 31 17:55:36 GMT 2025
|
PRIMARY | |||
|
215372
Created by
admin on Mon Mar 31 17:55:36 GMT 2025 , Edited by admin on Mon Mar 31 17:55:36 GMT 2025
|
PRIMARY | |||
|
WN91WG5WNT
Created by
admin on Mon Mar 31 17:55:36 GMT 2025 , Edited by admin on Mon Mar 31 17:55:36 GMT 2025
|
PRIMARY | |||
|
35628-03-6
Created by
admin on Mon Mar 31 17:55:36 GMT 2025 , Edited by admin on Mon Mar 31 17:55:36 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |