U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 14:20:19 GMT 2023
Edited
by admin
on Sat Dec 16 14:20:19 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
WM18Z62RTI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Zigakibart
INN  
Official Name English
BION1301
Code English
Immunoglobulin G4 [229-proline], anti-(human proliferation-inducing ligand protein) (human-Mus musculus monoclonal BION-1301 γ4-chain), disulfide with human-Mus musculus monoclonal BION-1301 κ-chain, dimer
Common Name English
ANTI-TNFSF13 MONOCLONAL ANTIBODY BION-1301
Common Name English
zigakibart [INN]
Common Name English
ANTI-A PROLIFERATION-INDUCING LIGAND MONOCLONAL ANTIBODY BION-1301
Common Name English
BION-1301
Code English
ANTI-APRIL MONOCLONAL ANTIBODY BION-1301
Common Name English
BION 1301 [WHO-DD]
Common Name English
immunoglobulin G4-kappa, anti-[Homo sapiens TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256)], humanized monoclonal antibody
Common Name English
Code System Code Type Description
INN
12304
Created by admin on Sat Dec 16 14:20:19 GMT 2023 , Edited by admin on Sat Dec 16 14:20:19 GMT 2023
PRIMARY
FDA UNII
WM18Z62RTI
Created by admin on Sat Dec 16 14:20:19 GMT 2023 , Edited by admin on Sat Dec 16 14:20:19 GMT 2023
PRIMARY
NCI_THESAURUS
C142822
Created by admin on Sat Dec 16 14:20:19 GMT 2023 , Edited by admin on Sat Dec 16 14:20:19 GMT 2023
PRIMARY
CAS
2642175-46-8
Created by admin on Sat Dec 16 14:20:19 GMT 2023 , Edited by admin on Sat Dec 16 14:20:19 GMT 2023
PRIMARY
From To
1_22 1_96
2_22 2_96
2_135 4_214
2_148 2_204
2_262 2_322
1_135 3_214
2_368 2_426
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_148 1_204
1_227 2_227
1_230 2_230
1_262 1_322
1_368 1_426
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_298
N 2_298
Related Record Type Details
TARGET -> INHIBITOR
Binding to recombinant human APRIL determined by BioLayer Interferometry
BINDING
Kd
TARGET -> INHIBITOR
Blocking potency of TACI binding to APRIL
BINDING
IC50
TARGET -> INHIBITOR
Binding to recombinant human APRIL determined by ELISA
BINDING
EC50
TARGET -> INHIBITOR
Blocking potency of BCMA binding to APRIL
BINDING
IC50
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL