Zigakibart

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:20:19 GMT 2023` Edited by `admin` on `Sat Dec 16 14:20:19 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	WM18Z62RTI
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Zigakibart

Official Name

English

BION1301

Code

English

Immunoglobulin G4 [229-proline], anti-(human proliferation-inducing ligand protein) (human-Mus musculus monoclonal BION-1301 γ4-chain), disulfide with human-Mus musculus monoclonal BION-1301 κ-chain, dimer

Common Name

English

ANTI-TNFSF13 MONOCLONAL ANTIBODY BION-1301

Common Name

English

zigakibart [INN]

Common Name

English

ANTI-A PROLIFERATION-INDUCING LIGAND MONOCLONAL ANTIBODY BION-1301

Common Name

English

BION-1301

Code

English

ANTI-APRIL MONOCLONAL ANTIBODY BION-1301

Common Name

English

BION 1301 [WHO-DD]

Common Name

English

immunoglobulin G4-kappa, anti-[Homo sapiens TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256)], humanized monoclonal antibody

Common Name

English

Code System Code Type Description

INN

12304

Created by admin on Sat Dec 16 14:20:19 GMT 2023 , Edited by admin on Sat Dec 16 14:20:19 GMT 2023

PRIMARY

FDA UNII

WM18Z62RTI

Created by admin on Sat Dec 16 14:20:19 GMT 2023 , Edited by admin on Sat Dec 16 14:20:19 GMT 2023

PRIMARY

NCI_THESAURUS

C142822

Created by admin on Sat Dec 16 14:20:19 GMT 2023 , Edited by admin on Sat Dec 16 14:20:19 GMT 2023

PRIMARY

CAS

2642175-46-8

Created by admin on Sat Dec 16 14:20:19 GMT 2023 , Edited by admin on Sat Dec 16 14:20:19 GMT 2023

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_135	4_214
2_148	2_204
2_262	2_322
1_135	3_214
2_368	2_426
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_148	1_204
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					75Y39ND994

TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13

TARGET -> INHIBITOR

Comments:

Binding to recombinant human APRIL determined by BioLayer Interferometry

Interaction Type:

BINDING

Qualification:

Kd

Amount:


					WT1FK1K5GV

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 13B

TARGET -> INHIBITOR

Comments:

Blocking potency of TACI binding to APRIL

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					75Y39ND994

TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13

TARGET -> INHIBITOR

Comments:

Binding to recombinant human APRIL determined by ELISA

Interaction Type:

BINDING

Qualification:

EC50

Amount:


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET -> INHIBITOR

Comments:

Blocking potency of BCMA binding to APRIL

Interaction Type:

BINDING

Qualification:

IC50

Amount:

Related Record Type Details


					WM18Z62RTI

Zigakibart

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL