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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 23:10:46 GMT 2025
Edited
by admin
on Tue Apr 01 23:10:46 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
WM18Z62RTI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BION-1301
Preferred Name English
Zigakibart
INN   USAN  
Official Name English
BION1301
Code English
C90401
Code English
C-90401
Code English
Zigakibart [WHO-DD]
Common Name English
immunoglobulin G4-kappa, anti-[Homo sapiens TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256)], humanized monoclonal antibody; gamma4 heavy chain humanized (1-448) [VH humanized (Homo sapiens IGHV1-3*01 (83,7%) -(IGHD) -IGHJ4*01 (
Common Name English
Immunoglobulin G4 [229-proline], anti-(human proliferation-inducing ligand protein) (human-Mus musculus monoclonal BION-1301 ?4-chain), disulfide with human-Mus musculus monoclonal BION-1301 ?-chain, dimer
Common Name English
ANTI-TNFSF13 MONOCLONAL ANTIBODY BION-1301
Common Name English
zigakibart [INN]
Common Name English
ANTI-A PROLIFERATION-INDUCING LIGAND MONOCLONAL ANTIBODY BION-1301
Common Name English
90401
Code English
ANTI-APRIL MONOCLONAL ANTIBODY BION-1301
Common Name English
BION 1301 [WHO-DD]
Common Name English
ZIGAKIBART [USAN]
Common Name English
immunoglobulin G4-kappa, anti-[Homo sapiens TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256)], humanized monoclonal antibody
Common Name English
Code System Code Type Description
INN
12304
Created by admin on Tue Apr 01 23:10:46 GMT 2025 , Edited by admin on Tue Apr 01 23:10:46 GMT 2025
PRIMARY
FDA UNII
WM18Z62RTI
Created by admin on Tue Apr 01 23:10:46 GMT 2025 , Edited by admin on Tue Apr 01 23:10:46 GMT 2025
PRIMARY
SMS_ID
300000040653
Created by admin on Tue Apr 01 23:10:46 GMT 2025 , Edited by admin on Tue Apr 01 23:10:46 GMT 2025
PRIMARY
NCI_THESAURUS
C142822
Created by admin on Tue Apr 01 23:10:46 GMT 2025 , Edited by admin on Tue Apr 01 23:10:46 GMT 2025
PRIMARY
USAN
LM-201
Created by admin on Tue Apr 01 23:10:46 GMT 2025 , Edited by admin on Tue Apr 01 23:10:46 GMT 2025
PRIMARY
CAS
2642175-46-8
Created by admin on Tue Apr 01 23:10:46 GMT 2025 , Edited by admin on Tue Apr 01 23:10:46 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_135 4_214
2_148 2_204
2_262 2_322
1_135 3_214
2_368 2_426
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_148 1_204
1_227 2_227
1_230 2_230
1_262 1_322
1_368 1_426
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_298
N 2_298
Related Record Type Details
TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13
TARGET -> INHIBITOR
Binding to recombinant human APRIL determined by BioLayer Interferometry
BINDING
Kd
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 13B
TARGET -> INHIBITOR
Blocking potency of TACI binding to APRIL
BINDING
IC50
TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13
TARGET -> INHIBITOR
Binding to recombinant human APRIL determined by ELISA
BINDING
EC50
TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17
TARGET -> INHIBITOR
Blocking potency of BCMA binding to APRIL
BINDING
IC50
Related Record Type Details
Zigakibart
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS Amount: PIDOLIC ACID SZB83O1W42
AMINO ACID REMOVAL [1_448] [2_448] C-TERMINUS Amount: LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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