U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 16:02:49 UTC 2023
Edited
by admin
on Thu Jul 06 16:02:49 UTC 2023
Protein Sub Type
Sequence Type REPRESENTIVE
Record UNII
WF082S23P7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BCR-ABL KINASE T315I MUTANT (IMATINIB RESISTANT)
Common Name English
BCR-ABL KINASE T315I MUTANT
Common Name English
Code System Code Type Description
FDA UNII
WF082S23P7
Created by admin on Thu Jul 06 16:02:50 UTC 2023 , Edited by admin on Thu Jul 06 16:02:50 UTC 2023
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
IC50
INHIBITOR->RESISTANT TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
NRC-AN-019 treatments were able to reduce leukemia symptoms significantly in both Baf3Wt and Baf3 (T315I) imatinib resistant leukemic mice.
INHIBITOR -> TARGET
nonphosphorylated form
Kd
INHIBITOR -> TARGET
INHIBITOR->RESISTANT TARGET
INHIBITOR -> TARGET
INHIBITOR->RESISTANT TARGET
INHIBITOR -> TARGET
IN BA/F3 CELLS PREVENT RESISTANCE
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL