TRIMETHOBENZAMIDE HYDROCHLORIDE

First approved in 1959

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H28N2O5.ClH
Molecular Weight	424.918
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TRIMETHOBENZAMIDE HYDROCHLORIDE

Structure Search

SMILES

Cl.COC1=CC(=CC(OC)=C1OC)C(=O)NCC2=CC=C(OCCN(C)C)C=C2

InChI

InChIKey=WIIZEEPFHXAUND-UHFFFAOYSA-N

InChI=1S/C21H28N2O5.ClH/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4;/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C21H28N2O5
Molecular Weight	388.4574
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/017530s024lbl.pdf
Curator's Comment: description was created based on several sources, including https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/017531s014lbl.pdf | http://www.sciencedirect.com/science/article/pii/B9781416002086500231 | https://www.ncbi.nlm.nih.gov/pubmed/23002952

Trimethobenzamide (trade names Tebamide, Tigan) is an antiemetic used to prevent nausea and vomiting. Trimethobenzamide is an antagonist of the D2 receptor, that affects the chemoreceptor trigger zone (CTZ) of the medulla oblongata to suppress nausea and vomiting. The oral bioavailability of trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; I.M. about 30 minutes after intramuscular administration. The onset action of trimethobenzamide for antiemetic effects is 10-40 minutes after oral administration and; 15-35 minutes after intramuscular administration. The duration of action is 3-4 hours. Trimethobenzamide is generally considered the most potent antiemetic that does not have effects on the serotonergic, dopaminergic, or histaminergic systems, so it has a lower likelihood of causing undesired side effects. Possible side effects include drowsiness, dizziness, headache, diarrhea, muscle cramps, and blurred vision. More serious adverse effects include skin rash, tremors, parkinsonism, and jaundice.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D2 receptor 311 Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25841474	Antagonist 2849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Postoperative nausea and vomiting 31 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/017531s014lbl.pdf	Primary		Approved 8583	TIGAN Approved Use INDICATIONS & USAGE Tigan is indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis. Launch Date 1974
Nausea associated with gastroenteritis 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/017530s024lbl.pdf	Primary		Approved 8583	TIGAN Approved Use INDICATIONS & USAGE Tigan is indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis. Launch Date 1974

C_max

Value	Dose	Analyte	Population
3729 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
3817 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
5211 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
3537 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
4002 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
3536 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
4219 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
3712 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
3982 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
3847 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
3863 ng/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Analyte	Population
10465 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10218 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
13647 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10581 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
10621 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
10041 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
10436 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
10448 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
11544 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
10371 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
9768 ng × h/mL REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Analyte	Population
6.8 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
7.8 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
7.4 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
7 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
6.7 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
7.8 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
7.8 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED
6.8 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
6.5 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	200 mg single, intramuscular dose: 200 mg route of administration: Intramuscular experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
8 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED
7.6 h REVIEW https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/017531_S010_TIGAN_CAPSULE_AP.pdf	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:	TRIMETHOBENZAMIDE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
			inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://link.springer.com/chapter/10.1007/978-3-319-98343-1_38 Page: 132.0

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-045980	http://www.3bsc.com/index/pro_info.php?id=82579
AA Blocks	AA00I9T1	https://www.aablocks.com/goods/Goods/detail?id=AA00I9T1
Aaron Chemicals	AR00IAKT	http://www.aaronchem.com/554-92-7
abcr GmbH	AB506024	http://www.abcr.de/shop/en/AB506024
AHH Chemical co.,ltd	MT-59937	http://www.ahhchemical.com/product/MT-59937.html
AK Scientific, Inc. (AKSCI)	V1615	http://www.aksci.com/item_detail.php?cat=V1615
Alfa Chemistry	AP554927	https://reagents.alfa-chemistry.com/product/trimethobenzamide-hydrochloride-cas-554-92-7-13070.html
Alichem	19140697	http://www.alichem.com/en/products/554-92-7.html
Ambeed	A148362	https://www.ambeed.com/products/554-92-7.html
Angel Pharmatech	AG-10884	http://www.angelpharmatech.com/554-92-7.html
Ark Pharm	AK140655	http://www.arkpharminc.com/products/554-92-7.html
BLD Pharm	BD155412	http://www.bldpharm.com/products/554-92-7.html
BOC Sciences	554-92-7	https://www.bocsci.com/trimethobenzamide-hydrochloride-cas-554-92-7-item-124935.html
Chem Scene	CS-7696	http://www.chemscene.com/554-92-7.html
ChemMol	99105043	http://www.chemmol.com/chemmol/99105043.html
Chemspace	CSSB00000087811	https://chem-space.com/CSSB00000087811
Clearsynth	CS-T-62450	https://www.clearsynth.com/en/CST62450.html
Combi-Blocks	QW-6647	http://www.combi-blocks.com/cgi-bin/find.cgi?QW-6647
CSNpharm	CSN23250	https://www.csnpharm.com/products/trimethobenzamide-hcl.html
eNovation Chemicals	D673676	https://www.enovationchem.com/ProductDetails.asp?ProductID=D673676
eNovation Chemicals	D765721	https://www.enovationchem.com/ProductDetails.asp?ProductID=D765721
Finetech	FT-0736653	http://www.finetechnology-ind.com/prod/detail/pub/554-92-7.html
Lab Network	LN01309622	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01309622
LGC Standards	LGCFOR3281.00	https://www.lgcstandards.com/US/en/p/LGCFOR3281.00
LGC Standards	MM3281.00	https://www.lgcstandards.com/US/en/p/MM3281.00
mcule	MCULE-6632962832	https://mcule.com/MCULE-6632962832/
MedChem Express	HY-12751A	https://www.medchemexpress.com/Trimethobenzamide_hydrochloride.html
Molcore	MC560181	https://www.molcore.com/product/554-92-7
MolPort	MolPort-003-666-301	https://www.molport.com/shop/molecule-link/MolPort-003-666-301
OChem	30706	http://www.ocheminc.com/index.php?act=psearch&pid=554T927
Selleck Chemicals	S5483	http://www.selleckchem.com/products/trimethobenzamide-hydrochloride.html
Smolecule	S545892	http://www.smolecule.com/products/s545892
TCI (Tokyo Chemical Industry)	T3525	http://www.tcichemicals.com/eshop/en/us/commodity/T3525/index.html
THE BioTek	bt-287008	https://www.thebiotek.com/product/inhibitors/bt-287008

PubMed

Title	Date	PubMed
Screening of a chemical library reveals novel PXR-activating pharmacologic compounds.	2015-01-05	25455453
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010-12	21818443
Fabry disease.	2010-11-22	21092187
Clinical and economic outcomes associated with potentially inappropriate prescribing in the elderly.	2010-01-01	20059286
Standardizing emergency department-based migraine research: an analysis of commonly used clinical trial outcome measures.	2010-01	20078439
Acute gastroenteritis: from guidelines to real life.	2010	21694853
Vestibulocochlear toxicity in a pair of siblings 15 years apart secondary to aspartame: two case reports.	2009-09-15	20126318
Apomorphine in the treatment of Parkinson disease and other movement disorders.	2009-04	19364250
New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells.	2009-03-30	19331692
Use of antiemetic agents in acute gastroenteritis: a systematic review and meta-analysis.	2008-09	18762604
[Apomorphine in off state--clinical experience].	2007-10-19	17941458
FDA halts sales of some anti-vomiting suppositories...and are cough medications effective in children?	2007-05	17595688
Acute gastroenteritis in children: role of anti-emetic medication for gastroenteritis-related vomiting.	2007	17523698
Treatment of polydrug-using opiate dependents during withdrawal: towards a standardisation of treatment.	2006-11-15	17107609
Effects of rivastigmine on cognitive function in patients with traumatic brain injury.	2006-09-12	16966534
Anesthesiologists' practice patterns for treatment of postoperative nausea and vomiting in the ambulatory Post Anesthesia Care Unit.	2006-06-01	16740165
A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines.	2006-06	16732839
10 questions about using apomorphine for Parkinson disease.	2005-05	15860144
"Seeing catatonia".	2005	16387999
Trimethobenzamide in elderly patients.	2004-06	15182103
Practical considerations in the use of apomorphine injectable.	2004-03-23	15037670
Rapid treatment of "wearing off" in Parkinson's disease.	2004-03-23	15037669
Prescription medication use during pregnancy and risk of infant leukemia (United States).	2003-06	12946039
Intranasal apomorphine rescue therapy for parkinsonian "off" periods.	1996-06	8726538
Prune belly syndrome and heart defect in one of monozygotic twins, following exposure to Tigan and Bendectin.	1985	4050288
Trimethobenzamide HCl in the treatment of nausea and vomiting associated with antineoplastic chemotherapy.	1980-05-01	7400373
Studies of drugs given before anaesthesia. X. Two non-phenothiazine anti-emetics--cyclizine and trimethobenzamide.	1966-01	5908416
Use of Trimethobenzamide (Tigan) in Anesthesia.	1960-12-24	20326574

Patents

Sample Use Guides

In Vivo Use Guide

Usual Adult intramuscular dosage: 2 mL (200 mg) t.i.d. or q.i.d. . Usual Adult oral dosage: 300 mg orally three or four times daily. Usual Adult Rectal dosage: 200 mg 3-4 times a day.

Route of Administration: Other

In Vitro Use Guide

Rat embryos were used for activity evaluation. Embryos were explanted on day 9.5 of gestation and cultured. Whole rat serum was used as a culture medium for the control group while different concentrations of dimenhydrinate (2.5–20 lg/ml), metoclopramide (10–50 lg/ml) and trimethobenzamide HCl (25–100 lg/ml) were added to serum for the experimental groups.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:32:07 GMT 2025` Edited by `admin` on `Mon Mar 31 18:32:07 GMT 2025`
Record UNII	WDQ5P1SX7Q
Record Status	`Validated (UNII)`
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Name

Type

Language

TRIMETHOBENZAMIDE HYDROCHLORIDE

Common Name

English

TIGAN

Preferred Name

English

TRIMETHOBENZAMIDE HYDROCHLORIDE [MART.]

Common Name

English

BENZAMIDE, N-((4-(2-(DIMETHYLAMINO)ETHOXY)PHENYL)METHYL)-3,4,5-TRIMETHOXY-, MONOHYDROCHLORIDE

Common Name

English

Trimethobenzamide hydrochloride [WHO-DD]

Common Name

English

TRIMETHOBENZAMIDE HYDROCHLORIDE [USP-RS]

Common Name

English

NSC-37882

Code

English

TRIMETHOBENZAMIDE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

TRIMETHOBENZAMIDE HYDROCHLORIDE [MI]

Common Name

English

N-(P-(2-(DIMETHYLAMINO)ETHOXY)BENZYL)-3,4,5-TRIMETHOXYBENZAMIDE MONOHYDROCHLORIDE

Common Name

English

TRIMETHOBENZAMIDE HYDROCHLORIDE [USP MONOGRAPH]

Common Name

English

TRIMETHOBENZAMIDE HCL

Common Name

English

TRIMETHOBENZAMIDE HYDROCHLORIDE [VANDF]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C267