Elebsiran

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 15:54:52 GMT 2025` Edited by `admin` on `Wed Apr 02 15:54:52 GMT 2025`
Nucleic Acid Type	siRNA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	W982Y6N4X7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALN-81890 FREE ACID

Preferred Name

English

Elebsiran

Official Name

English

ELEBSIRAN [USAN]

Common Name

English

VIR-2218

Code

English

VIR 2218 [WHO-DD]

Code

English

RNA, (Gm-sp-Um-sp-Gm-Um-(2?-deoxy-2?-fluoro)G-Cm-(2?-deoxy-2?-fluoro)A-(2?-deoxy-2?-fluoro)C-(2?-deoxy-2?-fluoro)U-Um-Cm-Gm-Cm-Um-Um-Cm-Am-Cm-Am), 3?-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-?-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamin

Common Name

English

elebsiran [INN]

Common Name

English

Code System Code Type Description

USAN

LM-78

Created by admin on Wed Apr 02 15:54:52 GMT 2025 , Edited by admin on Wed Apr 02 15:54:52 GMT 2025

PRIMARY

NCI_THESAURUS

C190492

Created by admin on Wed Apr 02 15:54:52 GMT 2025 , Edited by admin on Wed Apr 02 15:54:52 GMT 2025

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INN

12341

Created by admin on Wed Apr 02 15:54:52 GMT 2025 , Edited by admin on Wed Apr 02 15:54:52 GMT 2025

PRIMARY

FDA UNII

W982Y6N4X7

Created by admin on Wed Apr 02 15:54:52 GMT 2025 , Edited by admin on Wed Apr 02 15:54:52 GMT 2025

PRIMARY

CAS

2648009-64-5

Created by admin on Wed Apr 02 15:54:52 GMT 2025 , Edited by admin on Wed Apr 02 15:54:52 GMT 2025

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SMS_ID

300000033013

Created by admin on Wed Apr 02 15:54:52 GMT 2025 , Edited by admin on Wed Apr 02 15:54:52 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_2;1_8-1_9;1_14;1_16;2_5;2_7-2_9	9 / 41
S Propanetriol (GNA sugar)	1_6	1 / 41
2'-O-Methoxyethyl ribose	1_1;1_3-1_5;1_7;1_10-1_13;1_15;1_17-1_21;2_1-2_4;2_6;2_10-2_20	31 / 41

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_3;1_20-1_21;2_2-2_3	6 / 39
Phosphate	1_4-1_19;2_4-2_20	33 / 39

Related Record Type Details


					GM9T93L85E

Elebsiran sodium

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					W982Y6N4X7

Elebsiran

ACTIVE MOIETY

Interaction Type:

PRECLINICAL

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[2_20]	3'-TERMINUS			ZILEBESIRAN 3'-MODIFICATION	UM4X8S48E7
NUCLEOTIDE SUBSTITUTION	[1_6]				1-((2S)-1-(2,3-DIHYDROXY)PROPYL)THYMINE-PHOSPHATE	3BH2CF5QM5

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL