2'-O-METHYLGUANOSINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H15N5O5
Molecular Weight	297.2673
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=NC3=C2N=C(N)NC3=O

InChI

InChIKey=OVYNGSFVYRPRCG-KQYNXXCUSA-N

InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C11H15N5O5
Molecular Weight	297.2673
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Facile and efficient approach for the synthesis of N(2)-dimethylaminomethylene-2'-O-methylguanosine.	2010-01-01	19945873
The thermodynamics of 3'-terminal pyrene and guanosine for the design of isoenergetic 2'-O-methyl-RNA-LNA chimeric oligonucleotide probes of RNA structure.	2008-02-05	18177022
Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling.	2007-11-29	18047657
An efficient process for synthesis of 2'-O-methyl and 3'-O-methyl guanosine from 2-aminoadenosine using diazomethane and the catalyst stannous chloride.	2006-03	16629123
A relaxed discrimination of 2'-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B.	2005-02-25	15561709
Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.	2005-02-24	15715486
Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.	2004-04-22	15084127
MDPSCL2: a new protecting group for chemoselective synthesis of 2'-O-alkylated guanosines.	2003-10-21	14565233
Novel synthesis of 2'-O-methylguanosine.	2003-05-19	12729629
Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2'-O-methyl-guanosine-uridine quadruplex motifs.	2003-04	12654739
Identification and characterization of tRNA (Gm18) methyltransferase from Thermus thermophilus HB8: domain structure and conserved amino acid sequence motifs.	2002-03	11918670
Anticodon domain methylated nucleosides of yeast tRNA(Phe) are significant recognition determinants in the binding of a phage display selected peptide.	2001-11-27	11714272

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:19:03 GMT 2025` Edited by `admin` on `Mon Mar 31 19:19:03 GMT 2025`
Record UNII	W722H4PA1S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2'-O-METHYLGUANOSINE

Systematic Name

English

GUANOSINE, 2'-O-METHYL-

Preferred Name

English

Code System Code Type Description

MESH

C024900