Approval Year
Substance Class |
Nucleic Acid
Created
by
admin
on
Edited
Sat Dec 16 19:01:05 GMT 2023
by
admin
on
Sat Dec 16 19:01:05 GMT 2023
|
Nucleic Acid Type | OLIGONUCLEOTIDE |
Nucleic Acid Subtype | ANTI-SENSE |
Sequence Origin | SYNTHETIC |
Sequence Type | COMPLETE |
Record UNII |
W6YJ85G6YG
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Record Status |
Validated (UNII)
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Record Version |
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-
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Code System | Code | Type | Description | ||
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W6YJ85G6YG
Created by
admin on Sat Dec 16 19:01:05 GMT 2023 , Edited by admin on Sat Dec 16 19:01:05 GMT 2023
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C188648
Created by
admin on Sat Dec 16 19:01:05 GMT 2023 , Edited by admin on Sat Dec 16 19:01:05 GMT 2023
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12351
Created by
admin on Sat Dec 16 19:01:05 GMT 2023 , Edited by admin on Sat Dec 16 19:01:05 GMT 2023
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JK-207
Created by
admin on Sat Dec 16 19:01:05 GMT 2023 , Edited by admin on Sat Dec 16 19:01:05 GMT 2023
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2589926-20-3
Created by
admin on Sat Dec 16 19:01:05 GMT 2023 , Edited by admin on Sat Dec 16 19:01:05 GMT 2023
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PRIMARY |
Sugar | Site Range | Site Count |
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D-Ribose (RNA) | 1_4-1_13 | 10 / 16 |
1_3;1_14-1_15 | 3 / 16 | |
2'-O-Methoxyethyl ribose | 1_1-1_2;1_16 | 3 / 16 |
Linkage | Site Range | Site Count |
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Phosporothioate | 1_2;1_5-1_14;1_16 | 12 / 15 |
Phosphate | 1_3-1_4;1_15 | 3 / 15 |
Related Record | Type | Details | ||
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ACTIVE MOIETY |
The LICA technology incorporated in ION904 a
triantennary N-acetyl galactosamine (GalNAc) moiety which targets the asialoglycoprotein
receptors (ASGPR) expressed abundantly on the hepatocyte cell surface, resulting in antisense mediated inhibition of angiotensinogen (AGT) expression within the hepatocyte
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Structural Modifications
Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
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NUCLEOSIDE BASE SUBSTITUTION | [1_3] [1_12] [1_13] | 5-METHYLCYTOSINE | 6R795CQT4H | |||
NUCLEOTIDE SUBSTITUTION | [1_1] | 5'-TERMINUS | ISIS-757456 CYTOSINE PHOSPHATE 5'-MODIFICATION | 49G0W4AL3R |