TAK-603

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H26N4O6
Molecular Weight	478.4971
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C(C2=CC(OC)=C(OC)C=C2)C3=C(C=C(OC)C(OC)=C3)N=C1CN4C=NC=N4

InChI

InChIKey=CLQRMSBSMHXMMC-UHFFFAOYSA-N

InChI=1S/C25H26N4O6/c1-6-35-25(30)24-18(12-29-14-26-13-27-29)28-17-11-22(34-5)21(33-4)10-16(17)23(24)15-7-8-19(31-2)20(9-15)32-3/h7-11,13-14H,6,12H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C25H26N4O6
Molecular Weight	478.4971
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8880222 | https://www.ncbi.nlm.nih.gov/pubmed/9370927 | https://adisinsight.springer.com/drugs/800006011

TAK-603 is a quinoline derivative, originally developed as a anti-rheumatic drug. TAK-603 selectively suppresses Th1 cytokine production. In animal models TAK-603 has the ability to suppress the immune system and protect cartilage from destruction. The development of TAK-603 has been discontinued.

Originator

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

In adjuvant arthritic (AA) rats, TAK-603 inhibited the hind paw swelling and the body weight loss. The minimum effective dose was 3.13 mg/kg/day (p.o.).

Route of Administration: Oral

In Vitro Use Guide

TAK-603 suppressed the mitogen-induced proliferation of mouse lymphocytes and the ConA-induced IFN-gamma and IL-2 production by rat lymphocytes at 0.1 to 10 uM

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:28:41 GMT 2023` Edited by `admin` on `Fri Dec 15 15:28:41 GMT 2023`
Record UNII	W6RZK26FCB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TAK-603

Common Name

English

ETHYL 4-(3,4-DIMETHOXYPHENYL)-6,7-DIMETHOXY-2-(1,2,4-TRIAZOL-1-YLMETHYL)QUINOLINE-3-CARBOXYLATE

Systematic Name

English

3-QUINOLINECARBOXYLIC ACID, 4-(3,4-DIMETHOXYPHENYL)-6,7-DIMETHOXY-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-, ETHYL ESTER

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

112698