PURINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H4N4
Molecular Weight	120.1121
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N1C=NC2=C1C=NC=N2

InChI

InChIKey=KDCGOANMDULRCW-UHFFFAOYSA-N

InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)

HIDE SMILES / InChI

Molecular Formula	C5H4N4
Molecular Weight	120.1121
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Purine but not pyrimidine nucleotides support rotation of F(1)-ATPase.	2001-07-06	11279248
Apoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinase.	2001-06-29	11294860
Feedback inhibition of amidophosphoribosyltransferase regulates the rate of cell growth via purine nucleotide, DNA, and protein syntheses.	2001-06-15	11290738
Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases.	2001-05	11306702
Novel treatment strategies in chronic lymphocytic leukemia.	2001-05	11296131
VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent.	2001-05	11288107
Characterization of nucleoside transport systems in cultured rat epididymal epithelium.	2001-05	11287319
Pdx-1 is required for activation in vivo from a duodenum-specific enhancer.	2001-04-27	11278481
A fluorescent sensor of the phosphorylation state of nucleoside diphosphate kinase and its use to monitor nucleoside diphosphate concentrations in real time.	2001-04-24	11305926
Lack of catalytic activity of a murine mRNA cytoplasmic serine hydroxymethyltransferase splice variant: evidence against alternative splicing as a regulatory mechanism.	2001-04-24	11305908
The beta ' subunit of Escherichia coli RNA polymerase is not required for interaction with initiating nucleotide but is necessary for interaction with rifampicin.	2001-04-20	11278820
Binding of nucleotides to nucleoside diphosphate kinase: a calorimetric study.	2001-04-17	11294625
Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.	2001-04-13	11292348
Selective recognition of pyrimidine motif triplexes by a protein encoded by the bacterial transposon Tn7.	2001-04-13	11292332
Prebiotic synthesis of nucleotides.	2001-04-12	11296526
15-mer DNA duplexes containing an abasic site are thermodynamically more stable with adjacent purines than with pyrimidines.	2001-04-03	11300765
UDP hydrolase activity associated with the porcine liver annexin fraction.	2001-04-03	11287124
Analysis of peroxynitrite reactions with guanine, xanthine, and adenine nucleosides by high-pressure liquid chromatography with electrochemical detection: C8-nitration and -oxidation.	2001-04	11304133
Synthesis and characterization of nucleosides and oligonucleotides bearing adducts of butadiene epoxides on adenine n(6) and guanine n(2).	2001-04	11304126
Functional characterization of a maize purine transporter by expression in Aspergillus nidulans.	2001-04	11283348
Ascorbic acid changes the pattern of purine metabolism during germination of white spruce somatic embryos.	2001-04	11282575
Purine-mediated signalling in pain and visceral perception.	2001-04	11282418
Local changes in GC/AT substitution biases and in crossover frequencies on Drosophila chromosomes.	2001-04	11264413
The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury.	2001-04	11264257
Activation of glutamate uptake by guanosine in primary astrocyte cultures.	2001-03-26	11277601
Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation.	2001-03-23	11254391
Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes.	2001-03-14	11248218
The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography.	2001-03-06	11258886
UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.	2001-03-01	11239487
Nucleoside transporters of parasitic protozoa.	2001-03	11286799
Active intestinal absorption of nucleosides by Na+-dependent transport across the brush border membrane in cows.	2001-03	11286414
Gas-phase hydrogen/deuterium exchange of positively charged mononucleotides by use of Fourier-transform ion cyclotron resonance mass spectrometry.	2001-03	11281602
Cell cycle in the fucus zygote parallels a somatic cell cycle but displays a unique translational regulation of cyclin-dependent kinases.	2001-03	11251098
A kinetic study on the interaction of deprotonated purine radical cations with amino acids and model peptides.	2001-02-15	11254212
Determination of urinary methylated purine pattern by high-performance liquid chromatography.	2001-02-10	11232859
Candida tropicalis and Penicillium marneffei mixed fungaemia in a patient with Waldenström's macroglobulinaemia.	2001-02	11305468
Inhibition of peroxynitrite-induced dityrosine formation with oxidized and reduced thiols, nitric oxide donors, and purine derivatives.	2001-02	11291595
Blood purine and energy status in rats with colitis.	2001-02	11281197
Disturbance of purine nucleotide metabolism: a possible early key event in development of intestinal damage induced by chemotherapy.	2001-02	11281171
Regulation of hisHF transcription of Aspergillus nidulans by adenine and amino acid limitation.	2001-02	11277623
Uric acid mediates photodynamic inactivation of caprine alpha-2-macroglobulin.	2001-02	11264889
Characterization of DNA damage at purine residues in oligonucleotides and calf thymus DNA induced by the mutagen 1-nitrosoindole-3-acetonitrile.	2001-02	11258964
Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury.	2001-02	11246323
Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells.	2001-02	11234887
[Pharmacological profiles of mycophenolate mofetil (CellCept), a new immunosuppressive agent].	2001-02	11233304
Effect of furosemide on renal excretion of oxypurinol and purine bases.	2001-02	11229436
Binding site of Fe3+ at purine of ATP as studied by NMR.	2001-01-15	11237248
6-mercaptopurine dosage and pharmacokinetics influence the degree of bone marrow toxicity following high-dose methotrexate in children with acute lymphoblastic leukemia.	2001-01	11243403
Genome-wide analysis of protein-DNA interactions in living cells.	2001	11305945
beta-Amyloid protein induces the formation of purine dimers in cellular DNA.	2001	11255222

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:34:08 GMT 2025` Edited by `admin` on `Mon Mar 31 19:34:08 GMT 2025`
Record UNII	W60KTZ3IZY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PURINE

Systematic Name

English

NSC-753

Preferred Name

English

1H-PURINE [MI]

Common Name

English

Classification Tree Code System Code

LOINC

85379-6