EVAZARSEN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 15:06:39 GMT 2023` Edited by `admin` on `Sat Dec 16 15:06:39 GMT 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	W3077QR2KG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EVAZARSEN SODIUM

Official Name

English

EVAZARSEN SODIUM [USAN]

Common Name

English

ISIS-757456 SODIUM

Code

English

ALL-P-AMBO-5'-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXYL))PHOSPHO)-2'-O-(2-METHOXYETHYL)-5-METHYL-P-THIOCYTIDYLYL-(3'-O->5'-O)-2'-O-(2-METHOXYETHYL)-P-THIOAD

Systematic Name

English

DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RA-A-M5C-A-A-G-M5C-T-G-G-T-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RG-(

Systematic Name

English

ISIS-757456 SODIUM-5'-GALNAC CONJUGATE

Code

English

Code System Code Type Description

NCI_THESAURUS

C188646

Created by admin on Sat Dec 16 15:06:39 GMT 2023 , Edited by admin on Sat Dec 16 15:06:39 GMT 2023

PRIMARY

FDA UNII

W3077QR2KG

Created by admin on Sat Dec 16 15:06:39 GMT 2023 , Edited by admin on Sat Dec 16 15:06:39 GMT 2023

PRIMARY

USAN

JK-206

Created by admin on Sat Dec 16 15:06:39 GMT 2023 , Edited by admin on Sat Dec 16 15:06:39 GMT 2023

PRIMARY

CAS

2589926-24-7

Created by admin on Sat Dec 16 15:06:39 GMT 2023 , Edited by admin on Sat Dec 16 15:06:39 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_6-1_15	10 / 20
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_1-1_19	19 / 19

Related Record Type Details


					P048YHG804

Evazarsen

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					P048YHG804

Evazarsen

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_19] [1_20]	SITE_SPECIFIC	2'-O-(2-METHOXYETHYL)-5-METHYLURIDINE	9Q36I4D9VB
NUCLEOSIDE_SUBSTITUTION	[1_7] [1_11]	SITE_SPECIFIC	5-METHYLDEOXYCYTIDINE	B200GV71QM
NUCLEOSIDE_SUBSTITUTION	[1_3] [1_16]	SITE_SPECIFIC	2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE	AOQ54IZZ6J
NUCLEOSIDE_SUBSTITUTION	[1_1]	5'-TERMINUS	UNSPECIFIED SUBSTANCE	708789d3 (not in database)