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Details

Stereochemistry ACHIRAL
Molecular Formula C6H13NO5
Molecular Weight 179.1711
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRICINE

SMILES

OCC(CO)(CO)NCC(O)=O

InChI

InChIKey=SEQKRHFRPICQDD-UHFFFAOYSA-N
InChI=1S/C6H13NO5/c8-2-6(3-9,4-10)7-1-5(11)12/h7-10H,1-4H2,(H,11,12)

HIDE SMILES / InChI

Molecular Formula C6H13NO5
Molecular Weight 179.1711
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Tricine is an organic derivative of tris and glycine used in buffer solutions. It is a zwitterionic amino acid with a useful buffering range of pH 7.4-8.8 and is one of Good's buffering agents; Good first prepared tricine to buffer chloropast reactions. Tricine is a commonly used electrophoresis buffer and is also used in resuspension of cell pellets. Tricine–SDS-PAGE, based on Tricine-Tris buffer systems, is the commonly used SDS electrophoretic techniques for separating proteins. [99mTc]Tricine is a useful precursor complex for the radiolabeling of hydrazinonicotinate protein conjugates.

Approval Year

PubMed

PubMed

TitleDatePubMed
A comparative approach towards thylakoid membrane proteome analysis of unicellular green alga Scenedesmus obliquus.
2007-09
99mTc-labelled HYNIC-minigastrin with reduced kidney uptake for targeting of CCK-2 receptor-positive tumours.
2007-08
Determination of serum glucose by horseradish peroxidase-catalysed imidazole chemiluminescence coupled to a micro-flow-injection system.
2007-07-13
Oxidation of chylomicron remnant-like particles inhibits their uptake by THP-1 macrophages by apolipoprotein E-dependent processes.
2007-07
Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging.
2007-06-15
Recombinational micro-evolution of functionally different metallothionein promoter alleles from Orchesella cincta.
2007-06-11
A widespread picture of the Streptococcus thermophilus proteome by cell lysate fractionation and gel-based/gel-free approaches.
2007-05
Further characterization of ADAMTS-13 inactivation by thrombin.
2007-05
Site specific phosphorylation of cytochrome c oxidase subunits I, IVi1 and Vb in rabbit hearts subjected to ischemia/reperfusion.
2007-04-03
Elucidating the ticking of an in vitro circadian clockwork.
2007-04
The low molecular weight proteome of Halobacterium salinarum.
2007-04
Impact of trivalent arsenicals on selenoprotein synthesis.
2007-03
Comparison of sampling techniques for parallel analysis of transcript and metabolite levels in Saccharomyces cerevisiae.
2007-03
Imaging of disease dynamics during meningococcal sepsis.
2007-02-21
Human plasma ATP concentration.
2007-02
Distinction between pore assembly by staphylococcal alpha-toxin versus leukotoxins.
2007
[Synthesis and animal imaging of 99mTc-hydrazinonicotinamide-folate as a new folate receptor-targeted tumor imaging agent].
2006-12
Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent.
2006-12
Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegans.
2006-11-29
Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription.
2006-11-03
[99mTc]HYNIC-RGD for imaging integrin alphavbeta3 expression.
2006-11
Optical spectroscopic studies of light-harvesting by pigment-reconstituted peridinin-chlorophyll-proteins at cryogenic temperatures.
2006-10
[The use of a new analogue DGlu-Octagastrin in scintigraphy of medullary thyroid carcinoma].
2006-09-29
Possible involvement of integrin-mediated signalling in oocyte activation: evidence that a cyclic RGD-containing peptide can stimulate protein kinase C and cortical granule exocytosis in mouse oocytes.
2006-09-25
Dibenzazecine compounds with a novel dopamine/5HT2A receptor profile and 3D-QSAR analysis.
2006-09-15
A low temperature bonding of quartz microfluidic chip for serum lipoproteins analysis.
2006-09
In vivo tumor angiogenesis imaging with site-specific labeled (99m)Tc-HYNIC-VEGF.
2006-07
Genetic screens for mutations affecting development of Xenopus tropicalis.
2006-06
Asialoglycoprotein-receptor-targeted hepatocyte imaging using 99mTc galactosylated chitosan.
2006-05
Upregulation of a tonoplast-localized cytochrome P450 during petal senescence in Petunia inflata.
2006-04-13
A novel ternary ligand system useful for preparation of cationic (99m)Tc-diazenido complexes and (99m)Tc-labeling of small biomolecules.
2006-03-16
HTLV-I antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylated.
2006-03-02
The decay of the ATPase activity of light plus thiol-activated thylakoid membranes in the dark.
2006-02
Biochemical and morphological changes in endothelial cells in response to hypoxic interstitial edema.
2006-01-13
Tricine-SDS-PAGE.
2006
Generation of medaka gene knockout models by target-selected mutagenesis.
2006
Micromethods for the characterization of lipid A-core and O-antigen lipopolysaccharide.
2006
A novel Dictyostelium RasGEF required for chemotaxis and development.
2005-12-07
Human urine proteome analysis by three separation approaches.
2005-12
The weak bases NH(3) and trimethylamine inhibit the medium and slow afterhyperpolarizations in rat CA1 pyramidal neurons.
2005-12
Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates.
2005-11-29
Blue-native PAGE in plants: a tool in analysis of protein-protein interactions.
2005-11-16
Sodium glycylglycine as effective electrolyte run buffer for ascorbic and uric acid separation by CZE: a comparison with two other CE assays.
2005-11
Reconstitution and properties of the recombinant glyceraldehyde-3-phosphate dehydrogenase/CP12/phosphoribulokinase supramolecular complex of Arabidopsis.
2005-11
Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci.
2005-10-06
Analysis and separation of enkephalin and dalargin analogues and fragments by capillary zone electrophoresis.
2005-07-15
[99mTc] HYNIC-hEGF, a potential agent for imaging of EGF receptors in vivo: preparation and pre-clinical evaluation.
2005-06
Chondrocytes, synoviocytes and dermal fibroblasts all express PH-20, a hyaluronidase active at neutral pH.
2005
Molecular interactions of the type 1 human immunodeficiency virus transregulatory protein Tat with N-methyl-d-aspartate receptor subunits.
2005
Antimicrobial activity of lactic acid bacteria isolated from Tenerife cheese: initial characterization of plantaricin TF711, a bacteriocin-like substance produced by Lactobacillus plantarum TF711.
2005
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:21:43 GMT 2025
Edited
by admin
on Mon Mar 31 21:21:43 GMT 2025
Record UNII
W12LH4V8V3
Record Status Validated (UNII)
Record Version
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Name Type Language
NSC-369995
Preferred Name English
TRICINE
MI  
Systematic Name English
N-(TRIS(HYDROXYMETHYL)METHYL)GLYCINE
Systematic Name English
TRICINE [MI]
Common Name English
N-(2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL)GLYCINE
Systematic Name English
Code System Code Type Description
FDA UNII
W12LH4V8V3
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY
EPA CompTox
DTXSID1063982
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY
WIKIPEDIA
TRICINE
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY
ECHA (EC/EINECS)
227-193-6
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY
CHEBI
39063
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY
CAS
5704-04-1
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY
EVMPD
SUB31940
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY
SMS_ID
100000126991
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY
PUBCHEM
79784
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY
NSC
369995
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY
MERCK INDEX
m11086
Created by admin on Mon Mar 31 21:21:43 GMT 2025 , Edited by admin on Mon Mar 31 21:21:43 GMT 2025
PRIMARY Merck Index