GSK-1521498

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H20F2N4
Molecular Weight	402.4392
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC(=CC(F)=C1CNC2CC3=C(C2)C=CC=C3)C4=CC=CC(=C4)C5=NNC=N5

InChI

InChIKey=WIEDUMBCZQRGSY-UHFFFAOYSA-N

InChI=1S/C24H20F2N4/c25-22-11-19(15-6-3-7-18(8-15)24-28-14-29-30-24)12-23(26)21(22)13-27-20-9-16-4-1-2-5-17(16)10-20/h1-8,11-12,14,20,27H,9-10,13H2,(H,28,29,30)

HIDE SMILES / InChI

Molecular Formula	C24H20F2N4
Molecular Weight	402.4392
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23147384 | https://clinicaltrials.gov/ct2/show/NCT01195792 | https://www.drugbank.ca/drugs/DB12886 | https://www.ncbi.nlm.nih.gov/pubmed/26044906

GSK-1521498 is being tested for treatment of over-eating behaviors and other control-related eating problems. This compound inhibits the effects of opioids, which are known to be involved in controlling how much we eat and the pleasure associated with eating. GSK-1521498 has also been evaluated for treatment of alcoholism, potentially promoting abstinence and preventing relapse in alcohol addiction.

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:21:15 GMT 2025` Edited by `admin` on `Mon Mar 31 21:21:15 GMT 2025`
Record UNII	W0UTB622GK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GSK-1521498

Code

English

GSK1521498

Preferred Name

English

GSK1521498H

Code

English

N-((3,5-DIFLUORO-3'-(1H-1,2,4-TRIAZOL-3-YL)-4-BIPHENYLYL)METHYL(-2,3-DIHYDRO-1H-INDEN-2-AMINE

Common Name

English

Code System Code Type Description

PUBCHEM

24737629