Pridefine (AHR-1118) is a pyrrolidine derivative with clinically established antidepressant efficacy. Pridefine acted predominantly as a reuptake blocker of norepinephrine, dopamine, and 5-hydroxytryptamine, although some releasing activity was also present. Several clinical studies have demonstrated that pridefine is clinically as efficacious as imipramine and, perhaps more importantly, less toxic than standard antidepressants used.