FOSFLURIDINE TIDOXIL

Details

Stereochemistry	EPIMERIC
Molecular Formula	C34H62FN2O10PS
Molecular Weight	740.901
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCSCC(COP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O)OCCCCCCCCCC

InChI

InChIKey=LBBDGLOPGRGFDO-FKJRLRTPSA-N

InChI=1S/C34H62FN2O10PS/c1-3-5-7-9-11-13-14-16-18-20-22-49-26-27(44-21-19-17-15-12-10-8-6-4-2)24-45-48(42,43)46-25-29-30(38)31(39)33(47-29)37-23-28(35)32(40)36-34(37)41/h23,27,29-31,33,38-39H,3-22,24-26H2,1-2H3,(H,42,43)(H,36,40,41)/t27?,29-,30-,31-,33-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C34H62FN2O10PS
Molecular Weight	740.901
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	4 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ema.europa.eu/en/medicines/human/paediatric-investigation-plans/flosfluridine-tidoxil | https://adisinsight.springer.com/drugs/800019549

Flosfluridine tidoxil, a thymidylate synthase inhibitor that was developed for the treatment of actinic keratosis and solid tumors, e.g. breast and colorectal cancers. These studies were suspended and information about the further development of this drug is not available.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:42:39 GMT 2025` Edited by `admin` on `Mon Mar 31 18:42:39 GMT 2025`
Record UNII	VY3U311S3Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

5'-URIDYLIC ACID, 5-FLUORO-, MONO(2-(DECYLOXY)-3-(DODECYLTHIO)PROPYL) ESTER

Preferred Name

English

FOSFLURIDINE TIDOXIL

Official Name

English

5-FLUOROURIDINE 5'-((2RS)-2-(DECYLOXY)-3-(DODECYLSULFANYL)PROPYL HYDROGEN PHOSPHATE)

Systematic Name

English

fosfluridine tidoxil [INN]

Common Name

English

Code System Code Type Description

CAS

174638-15-4