N-(CARBOXYCARBONYL)GLYCINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H5NO5
Molecular Weight	147.0862
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

OC(=O)CNC(=O)C(O)=O

InChI

InChIKey=BIMZLRFONYSTPT-UHFFFAOYSA-N

InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)

HIDE SMILES / InChI

Molecular Formula	C4H5NO5
Molecular Weight	147.0862
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

N-(Carboxycarbonyl)glycine is a broad-spectrum inhibitor of many 2-oxoglutarate oxygenases. It is currently widely used in studies on the hypoxic response and chromatin modifications in animals.

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2,596

PubMed

Show entries

Title	Date	PubMed
Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.	2009 Nov 18	19924283
Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.	2010 Aug 12	20684604
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.	2010 Nov 23	21124847
Force field design and molecular dynamics simulations of factor-inhibiting HIF-1 and its complex with known inhibitors: implications for rational inhibitor design.	2010 Sep	20663694

Showing 1 to 4 of 4 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical
Record UNII	VVW38EB8YS
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

N-OXALYLGLYCINE

Preferred Name

English

N-(CARBOXYCARBONYL)GLYCINE

Systematic Name

English

NOG

Common Name

English

GLYCINE, N-(CARBOXYCARBONYL)-

Systematic Name

English

OXAMIC ACID, (CARBOXYMETHYL)-

Systematic Name

English

Showing 1 to 5 of 7 entries

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Code System

Code

Type

Description

EPA CompTox

DTXSID20200601

PRIMARY

CAS

5262-39-5

PRIMARY

CHEBI

44482

PRIMARY

PUBCHEM

3080614

PRIMARY

FDA UNII

VVW38EB8YS

PRIMARY

Showing 1 to 5 of 6 entries

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SMILES

InChI

Description<div class="info-popup-container"><div><span class="pop-sub-key ">Sources:&nbsp;</span><span class="pop-sub-val"><span class="ext-link"><a target="_self" href="https://www.ncbi.nlm.nih.gov/pubmed/26196940">https://www.ncbi.nlm.nih.gov/pubmed/26196940</a></span></span></div></div>

Approval Year

Conditions

PubMed

Patents

Sample Use Guides

Description