U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 13:42:37 UTC 2023
Edited
by admin
on Sat Dec 16 13:42:37 UTC 2023
Protein Type PEPTIDE
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
VVM1871S9U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2
Common Name English
C-IAP1
Common Name English
CELLULAR INHIBITOR OF APOPTOSIS 1
Common Name English
RING-TYPE E3 UBIQUITIN TRANSFERASE BIRC2
Common Name English
Code System Code Type Description
FDA UNII
VVM1871S9U
Created by admin on Sat Dec 16 13:42:37 UTC 2023 , Edited by admin on Sat Dec 16 13:42:37 UTC 2023
PRIMARY
UNIPROT
Q13490
Created by admin on Sat Dec 16 13:42:37 UTC 2023 , Edited by admin on Sat Dec 16 13:42:37 UTC 2023
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
APG-1387 in combination with TNF-α potently decreased NPC cell viability by inducing apoptosis in majority of NPC cell lines. Eight human IAP proteins and Smac mimetics activate caspases by antagonizing XIAP, which directly inhibits key caspase.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Small molecule second mitochondrial activator of caspase (SMAC) mimetic, which both disengages IAPs from caspases and induces proteasomal degradation of cIAP-1 and -2, resulting in altered signaling through the NFκB pathway
BINDING
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL