Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Tue Apr 01 21:10:55 GMT 2025
by
admin
on
Tue Apr 01 21:10:55 GMT 2025
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| Protein Type | PEPTIDE |
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
VVM1871S9U
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Common Name | English |
| Code System | Code | Type | Description | ||
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VVM1871S9U
Created by
admin on Tue Apr 01 21:10:55 GMT 2025 , Edited by admin on Tue Apr 01 21:10:55 GMT 2025
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PRIMARY | |||
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Q13490
Created by
admin on Tue Apr 01 21:10:55 GMT 2025 , Edited by admin on Tue Apr 01 21:10:55 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
APG-1387 in combination with TNF-? potently decreased NPC cell viability by inducing apoptosis in majority of NPC cell lines. Eight human IAP proteins and Smac mimetics activate caspases by antagonizing XIAP, which directly inhibits key caspase.
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Small molecule second mitochondrial activator of caspase (SMAC) mimetic, which both disengages IAPs from caspases and induces proteasomal degradation of cIAP-1 and -2, resulting in altered signaling through the NF?B pathway
BINDING
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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