BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 13:42:37 GMT 2023` Edited by `admin` on `Sat Dec 16 13:42:37 GMT 2023`
Protein Type	PEPTIDE
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	VVM1871S9U
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2

Common Name

English

C-IAP1

Common Name

English

CELLULAR INHIBITOR OF APOPTOSIS 1

Common Name

English

RING-TYPE E3 UBIQUITIN TRANSFERASE BIRC2

Common Name

English

Code System Code Type Description

FDA UNII

VVM1871S9U

Created by admin on Sat Dec 16 13:42:37 GMT 2023 , Edited by admin on Sat Dec 16 13:42:37 GMT 2023

PRIMARY

UNIPROT

Q13490

Created by admin on Sat Dec 16 13:42:37 GMT 2023 , Edited by admin on Sat Dec 16 13:42:37 GMT 2023

PRIMARY

Related Record Type Details


					N65WC8PXDD

Xevinapant

INHIBITOR -> TARGET

Amount:


					E53VN70K2X

Dasminapant

INHIBITOR -> TARGET

Comments:

APG-1387 in combination with TNF-α potently decreased NPC cell viability by inducing apoptosis in majority of NPC cell lines. Eight human IAP proteins and Smac mimetics activate caspases by antagonizing XIAP, which directly inhibits key caspase.

Amount:


					XE77D7FKW4

PROPANAMIDE, N-(5-(2-(2-METHOXY-3-PYRIDINYL)-7-METHYLIMIDAZO(1,2-A)PYRIDIN-3-YL)-6-(2-(1-METHYL-6-ISOQUINOLINYL)ETHYNYL)-2-PYRIDINYL)-2-(METHYLAMINO)-, (2S)-

INHIBITOR -> TARGET


					6O4Z07B57R

BIRINAPANT

INHIBITOR -> TARGET

Amount:


					6TNS415Y3P

LCL-161

INHIBITOR -> TARGET

Comments:

Small molecule second mitochondrial activator of caspase (SMAC) mimetic, which both disengages IAPs from caspases and induces proteasomal degradation of cIAP-1 and -2, resulting in altered signaling through the NFκB pathway

Interaction Type:

BINDING

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL