Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H7ClF2N2O |
| Molecular Weight | 268.647 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC1=CC=C(C=C1F)C(=O)NC2=CC=C(Cl)N=C2
InChI
InChIKey=GDGUOCFTHNGPBK-UHFFFAOYSA-N
InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18)
| Molecular Formula | C12H7ClF2N2O |
| Molecular Weight | 268.647 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Differential effects of ICA-27243 on cloned K(V)7 channels. | 2010 |
|
| The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. | 2009-11-13 |
|
| Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania. | 2009-03-17 |
|
| In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models. | 2008-09 |
|
| N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. | 2008-03 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:40:19 GMT 2025
by
admin
on
Mon Mar 31 22:40:19 GMT 2025
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| Record UNII |
VU7278D853
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| Record Status |
Validated (UNII)
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| Record Version |
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Created by
admin on Mon Mar 31 22:40:19 GMT 2025 , Edited by admin on Mon Mar 31 22:40:19 GMT 2025
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TARGET -> ACTIVATOR |
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ACTIVE MOIETY |
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