Details
Stereochemistry | ACHIRAL |
Molecular Formula | 2Na.O3S |
Molecular Weight | 126.043 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[O-]S([O-])=O
InChI
InChIKey=GEHJYWRUCIMESM-UHFFFAOYSA-L
InChI=1S/2Na.H2O3S/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
Molecular Formula | O3S |
Molecular Weight | 80.063 |
Charge | -2 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Sulfites are compounds that contain the sulfite ion. The sulfite ion is the conjugate base of bisulfite. Although its acid is elusive, its salts are widely used. Sulfite is used in the photography industry to protect developing solutions from oxidation, in the pulp and paper industry, in water treatment as an oxygen scavenger agent, as a desulfurizing and dechlorinating agent in the leather industry and as a bleaching agent in textile industry. Sodium sulfite is a component in many pharmaceuticals, which is effective to maintain the potency and stability of drugs. It is added to a number of drug preparations as an antioxidant and antimicrobial agent. Sulfite is used as a food preservative. Topical, oral or parenteral exposure to sulphites has been reported to induce a range of adverse clinical effects in sensitive individuals, ranging from dermatitis, urticaria, flushing, hypotension, abdominal pain and diarrhoea to life-threatening anaphylactic and asthmatic reactions. Exposure to the sulphites arises mainly from the consumption of foods and drinks that contain these additives; however, exposure may also occur through the use of pharmaceutical products, as well as in occupational settings. Sulfite is accepted for use as a food additive in Europe. Sodium sulfite is generally recognized as safe by FDA. It is included in FDA Inactive Ingredients Database (epidural, IM, IV, and SC injections; inhalation solution; ophthalmic solutions; oral syrups and suspensions; otic solutions; topical creams and emulsions). Included in nonparenteral medicines licensed in the UK.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Increased spontaneous activity of antibody-forming cells in the peripheral blood of patients with active SLE. | 1977 Apr |
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[Determination of fibrinogen concentration in blood plasma by the sulfite precipitation method]. | 1979 Jan-Feb |
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Molybdenum: an essential trace element. | 1993 Dec |
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Nutritional aspects of dissimilatory sulfate reduction in the human large intestine. | 1997 Nov |
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Sulfite is released by human neutrophils in response to stimulation with lipopolysaccharide. | 1998 Nov |
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Ahomocysteinemia in molybdenum cofactor deficiency. | 1998 Sep |
Sample Use Guides
The acceptable daily intake for sodium sulfite has been set at up to 350 mg/kg body-weight daily.
Route of Administration:
Oral
Sulfite was rapidly converted to sulfate by isolated rat hepatocytes at concentrations ranging from 200 umol/L to 2 mmol/L. Incubation of isolated rat hepatocytes with 0.5, 1, or 2 mmol/L sulfite resulted in a
time-dependent increase in the amount of free glutathione, but not cysteine, associated with the cells.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:49:24 UTC 2023
by
admin
on
Fri Dec 15 15:49:24 UTC 2023
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Record UNII |
VTK01UQK3G
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C802
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Food Contact Sustance Notif, (FCN No.) |
FCN NO. 513
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CODEX ALIMENTARIUS (GSFA) |
INS-221
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EPA PESTICIDE CODE |
78203
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JECFA EVALUATION |
INS-221
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86477
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VTK01UQK3G
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24437
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m10081
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SODIUM SULFITE
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Related Record | Type | Details | ||
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SOLVATE->ANHYDROUS |
Related Record | Type | Details | ||
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ACTIVE MOIETY |
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